Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations [electronic resource]

We present Rumi O-glucosylates the EGF repeats of a growing list of proteins essential in metazoan development, including Notch. Rumi is essential for Notch signaling, and Rumi dysregulation is linked to several human diseases. Despite Rumi's critical roles, it is unknown how Rumi glucosylates...

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Online Access: Online Access (via OSTI)
Corporate Author: Brookhaven National Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Washington, D.C. : Oak Ridge, Tenn. : United States. Department of Energy. Office of Basic Energy Sciences ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, 2016.
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Call Number: E 1.99:bnl--113513-2017-ja
E 1.99:bnl--113513-2017-ja Available