Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer

Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer [electronic resource]

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have demonstrated a 9% response rate in patients with locally advan...

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Bibliographic Details
Online Access: Online Access
Corporate Author: Lawrence Berkeley National Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2009.
Subjects:
Safety.
Patients.
In Vivo.
Sensitivity.
In Vitro.
Doxorubicin.
Motors.
Hair.
Mammary Glands.
Apoptosis.
Cell Cycle.
Exploration.
Proteins.
Neoplasms.
Mitosis.

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Call Number: E 1.99:lbnl-4328e
E 1.99:lbnl-4328e Available

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