Specificity of interaction between carcinogenic polynuclear aromatic hydrocarbons and nuclear proteins widespread occurrence of a restricted pattern of histone-binding in intact cells.

Specificity of interaction between carcinogenic polynuclear aromatic hydrocarbons and nuclear proteins [electronic resource] : widespread occurrence of a restricted pattern of histone-binding in intact cells.

Metabolic activation of benzo(a)pyrene (B(a)P) produces a number of potentially reactive metabolites. The endproducts of one metabolic pathway, 7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydro-B(a)P (BPDE) are responsible for essentially all DNA adduct formation in animal cells treated with B(a)P, and a p...

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Bibliographic Details
Online Access: Online Access
Corporate Author: Oak Ridge National Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Oak Ridge, Tenn. : Oak Ridge, Tenn. : Oak Ridge National Laboratory. ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 1982.
Subjects:
Binding Energy.
Labelled Compounds.
Organic Compounds.
Microsomes.
Organoids.
Somatic Cells.
Polycyclic Aromatic Hydrocarbons.
Benzopyrene.
Embryonic Cells.
Condensed Aromatics.
Proteins.
Tritium Compounds.
Adducts.
Metabolites.
Fibroblasts.
Cell Constituents.
Tracer Techniques.
Animal Cells.
Histones.
Cell Cultures.
Connective Tissue Cells.
Aromatics.
3-methylcholanthrene.
Isotope Applications.
Energy.
Hydrocarbons.
Benzanthracene.
Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..

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Call Number: E 1.99:conf-820439-6
E 1.99:conf-820439-6 Available

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