Comparison of benzo(a)pyrene metabolism and mutation induction in CHO cells using rat liver homogenate (S9) or Syrian hamster embryonic cell-mediated activation systems [electronic resource]
Mutagenesis in CHO cells has been studied by the addition of an ezymatically active liver homogenate (S9) fraction. However, the metabolism of procarcinogens, such as benzo(a)pyrene (B(a)P), by rat liver homogenate differs from that in intact cellular activation systems. Consequently, B(a)P-induced...
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Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Los Alamos, N.M. : Oak Ridge, Tenn. :
Los Alamos National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1981.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Comparison of benzo(a)pyrene metabolism and mutation induction in CHO cells using rat liver homogenate (S9) or Syrian hamster embryonic cell-mediated activation systems |h [electronic resource] |
| 260 | |a Los Alamos, N.M. : |b Los Alamos National Laboratory ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1981. | ||
| 300 | |a Pages: 8 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 01/01/1981. | ||
| 500 | |a "la-ur-81-3203" | ||
| 500 | |a " conf-811086-1" | ||
| 500 | |a "DE82002350" | ||
| 500 | |a 6. symposium on polycyclic aromatic hydrocarbons, Columbus, OH, USA, 27 Oct 1981. | ||
| 500 | |a Okinaka, R.T.; Chen, D.J.; Strniste, G.F. | ||
| 520 | 3 | |a Mutagenesis in CHO cells has been studied by the addition of an ezymatically active liver homogenate (S9) fraction. However, the metabolism of procarcinogens, such as benzo(a)pyrene (B(a)P), by rat liver homogenate differs from that in intact cellular activation systems. Consequently, B(a)P-induced mutation frequencies in mammalian cells may vary when different activation systems are used. This study attempts to compare B(a)P metabolism and conjugation in rat liver homogenate (S9 preparation) and in Syrian hamster embryonic (SHE) cells. Furthermore, a CHO mutation assay incorporating either of the activation systems is being used to measure the mutation induction frequency. | |
| 536 | |b W-7405-ENG-36. | ||
| 650 | 7 | |a Animal Cells. |2 local. | |
| 650 | 7 | |a Mutation Frequency. |2 local. | |
| 650 | 7 | |a Benzopyrene. |2 local. | |
| 650 | 7 | |a Mutagen Screening. |2 local. | |
| 650 | 7 | |a Cell Cultures. |2 local. | |
| 650 | 7 | |a Comparative Evaluations. |2 local. | |
| 650 | 7 | |a Hamsters. |2 local. | |
| 650 | 7 | |a Liver. |2 local. | |
| 650 | 7 | |a Metabolism. |2 local. | |
| 650 | 7 | |a Rats. |2 local. | |
| 650 | 7 | |a Animals. |2 local. | |
| 650 | 7 | |a Aromatics. |2 local. | |
| 650 | 7 | |a Body. |2 local. | |
| 650 | 7 | |a Condensed Aromatics. |2 local. | |
| 650 | 7 | |a Digestive System. |2 local. | |
| 650 | 7 | |a Glands. |2 local. | |
| 650 | 7 | |a Hydrocarbons. |2 local. | |
| 650 | 7 | |a Mammals. |2 local. | |
| 650 | 7 | |a Organic Compounds. |2 local. | |
| 650 | 7 | |a Organs. |2 local. | |
| 650 | 7 | |a Rodents. |2 local. | |
| 650 | 7 | |a Screening. |2 local. | |
| 650 | 7 | |a Vertebrates. |2 local. | |
| 650 | 7 | |a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.. |2 edbsc. | |
| 710 | 2 | |a Los Alamos National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
| 856 | 4 | 0 | |u http://www.osti.gov/scitech/biblio/5962661 |z Online Access |
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| 952 | f | f | |p Can circulate |a University of Colorado Boulder |b Online |c Online |d Online |e E 1.99: conf-811086-1 |h Superintendent of Documents classification |i web |n 1 |