Comparison of benzo(a)pyrene metabolism and mutation induction in CHO cells using rat liver homogenate (S9) or Syrian hamster embryonic cell-mediated activation systems

Comparison of benzo(a)pyrene metabolism and mutation induction in CHO cells using rat liver homogenate (S9) or Syrian hamster embryonic cell-mediated activation systems [electronic resource]

Mutagenesis in CHO cells has been studied by the addition of an ezymatically active liver homogenate (S9) fraction. However, the metabolism of procarcinogens, such as benzo(a)pyrene (B(a)P), by rat liver homogenate differs from that in intact cellular activation systems. Consequently, B(a)P-induced...

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Online Access: Online Access
Corporate Author: Los Alamos National Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, 1981.
Subjects:
Animal Cells.
Mutation Frequency.
Benzopyrene.
Mutagen Screening.
Cell Cultures.
Comparative Evaluations.
Hamsters.
Liver.
Metabolism.
Rats.
Animals.
Aromatics.
Body.
Condensed Aromatics.
Digestive System.
Glands.
Hydrocarbons.
Mammals.
Organic Compounds.
Organs.
Rodents.
Screening.
Vertebrates.
Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..

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Call Number: E 1.99: conf-811086-1
E 1.99: conf-811086-1 Available

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