Essential Guide to Blood Coagulation.
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| Online Access: |
Full Text (via ProQuest) |
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| Format: | eBook |
| Language: | English |
| Published: |
New York :
Wiley,
2013.
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| Edition: | 2nd ed. |
| Subjects: |
Table of Contents:
- Schematic presentation of the hemostatic system / Nils Egberg
- Proposals for sampling instructions / Margareta Blombäck and Nils Egberg
- Laboratory investigations / Jovan P. Antovic, Liselotte Onelöv, and Nils Egberg
- Hereditary bleeding disorders / Margareta Holmström and Lars-Göran Lundberg
- Critical bleeding / Maria Bruzelius, Anna Ågren, and Hans Johnsson
- Investigation of increased bleeding tendency / Margareta Holmström and Lars Göran Lundberg
- Venous thrombosis and pulmonary embolism / Anders Carlsson
- Investigations of thromboembolic tendency / Margareta Holmström
- Heart disease / Håkan Wallen and Rickard Linder
- Antiplatelet drug therapy and reversal of its effects / Håkan Wallen, Hans Johnsson, and Bo-Michael Bellander
- New oral anticoagulants : focus on currently approved oral factor Xa and thombin inhibitors / Rickard E. Malmström and Hans Johnsson
- Stroke and transient ischemic attack / Nils Wahlgren and Mia von Euler
- Peripheral artery surgery / Jesper Swedenborg
- Hemostasis in obstetrics and gynecology / Katarina Bremme
- Hemostasis in children / Susanna Ranta and Pia Petrini
- Emergency conditions associated with coagulation : DIC, HIT, and TTP/HUS / Jovan P. Antovic and Margareta Holmström.
- Part 1 General Hemostasis
- 1. Schematic presentation of the hemostatic system
- 2. Proposals for sampling instructions
- Points to note prior to sampling
- Sampling time and patient preparation
- Referrals for coagulation analyses
- Sampling
- Analyses of plasma
- Technique
- For DNA investigation (genetic analyses)
- Reference
- 3. Laboratory investigations
- Nomenclature
- Reference intervals for laboratory investigations
- Screening analyses
- Pt-Bleeding time
- Other proposed analyses when bleeding time is increased in spite of normal platelet count
- Special analyses
- Coagulation factors
- Anticoagulants
- Protein C anticoagulant system
- Platelet function
- Fibrinolysis
- Markers of coagulation activation (hypercoagulation markers)
- Activating peptides: general remarks
- P-prothrombin fragment 1+2 (F1+2)
- P-thrombin-antithrombin (TAT) complex
- DNA analyses
- DNA-based diagnosis of hemophilia A and B
- DNA-based diagnosis in VWD
- DNA-based diagnosis in other hereditary bleeding disorders
- DNA-based diagnosis in thromboembolic disorders
- Global hemostatic assays and bedside methods
- Endogenous thrombin potential (ETP)
- Overall hemostatic potential (OHP)
- Thromboelastography (TEG®)/ROTEM®)
- Point-of-care tests (POCT) also used as a routine
- Useful components in research studies
- Fibrin-gel structure
- P-plasmin-plasmin inhibitor complex
- P-t-PA-PAI complex
- P-thrombin time
- P-ecarin clotting time
- P-C1-esterase inhibitor
- P-elastase
- P-heparin co-factor II (HC II)
- P-plasminogen activator inhibitor 2 (PAI-2)
- P-protein C inhibitor
- P-APC-protein C inhibitor (PCI) complex
- P-Tafi
- P-VWF cleaving protease = ADAMTS-13
- P-tissue factor pathway inhibitor (TFPI)
- P-tissue factor (TF)
- Platelet-activating predictors
- P-thromboglobulin (β-TG), P-platelet factor 4 (PF4)
- Platelet P-selectin (CD62P) or P-soluble P-selectin
- PLT-fibrinogen, PLT-VWF
- Microparticles (MP)
- Other non-hemostatic variables of importance P/S-CRP
- Combinations of assays suggested for various hemostatic abnormalities
- References
- Part 2 Bleeding Disorders
- 4. Hereditary bleeding disorders
- General remarks about hemophilia A and B
- General remarks about von Willebrand disease
- Factor concentrates used for treatment of hemophilia A and B and VWD in Sweden in 2012
- General remarks about factor concentrates
- Treatment strategy in severe forms of hemophilia and VWD
- Home/self-treatment
- Treatment in trauma and acute bleedings
- Recommendations for desired initial plasma concentrations at different types of bleedings
- Prophylaxis against joint bleedings
- Surgery in patients with bleeding disorders
- Tooth extraction in a hemophilia patient
- Caution in patients with bleeding disorders
- Pain-killing drugs allowed in hemophilia
- Other important issues in more severe forms of hemophilia and VWD
- Risk of hepatitis
- Treatment principles for different types of bleeding disorders (severe, moderate, and milder forms of hemostatic defects)
- Hematuria
- Nose bleeding
- Gum bleeding
- Menorrhagia
- Pregnancy and delivery
- Treatment with tranexamic acid
- Contraindication
- Rare bleeding disorders
- Severe platelet function defect (e.g. Glanzmann thrombasthenia)
- Mild hemostatic defects
- Blood sampling in bleeding disorders
- Bleeding risk charts