Oral Bioavailability : Basic Principles, Advanced Concepts, and Applications / edited by Ming Hu, Xiaoling Li.

Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help ch...

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Bibliographic Details
Online Access: Full Text (via ProQuest)
Other Authors: Hu, Ming, Ph. D., Li, Xiaoling, 1957-
Format: eBook
Language:English
Published: Hoboken, N.J. : John Wiley & Sons, ©2011.
Subjects:
Table of Contents:
  • Frontmatter
  • Color Plates
  • Barriers to Oral Bioavailability--An Overview / Ming Hu, Xiaoling Li
  • Physicochemical Characterization of Pharmaceutical Solids / Smita Debnath
  • Solubility of Pharmaceutical Solids / Lauren Wiser, Xiaoling Gao, Bhaskara Jasti, Xiaoling Li
  • Dissolution of Pharmaceutical Solids / Josephine L P Soh, Paul W S Heng
  • Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption / Paul C Ho
  • Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways / Miki Susanto Park, Jae H Chang
  • Correlations of Pharmaceutical Dosage Forms / Deliang Zhou, Yihong Qiu
  • Drug Metabolism in Gastrointestinal Tract / Rashim Singh, Ming Hu
  • Efflux of Drugs via Transporters--The Antiabsorption Pathway / Jae H Chang, James A Uchizono, Miki Susanto Park
  • Liver Drug Metabolism / Leslie M Tompkins, Hongbing Wang
  • Protein Binding of Drugs / Antonia Kotsiou, Christine Tesseromatis
  • Urinary Excretion of Drugs and Drug Reabsorption / Pankaj Gupta, Bo Feng, Jack Cook
  • Pharmacokinetic Behaviors of Orally Administered Drugs / Jaime A Yez, Dion R Brocks, Laird M Forrest, Neal M Davies
  • Effects of Food on Drug Absorption / Venugopal P Marasanapalle, Xiaoling Li, Bhaskara R Jasti
  • Drug₆Drug Interactions and Drug-Dietary Chemical Interactions / Ge Lin, Zhong Zuo, Na Li, Li Zhang
  • Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans / Ayman El-Kattan, Susan Hurst, Joanne Brodfuehrer, Cho-Ming Loi
  • Amino Acid Drug Transporters / Zhong Qiu, Ming Hu
  • Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals / David J Lindley, Stephen M Carl, Dea Herrera-Ruiz, Li F Pan, Lori B Karpes, Jonathan M E Goole, Olafur S Gudmundsson, Gregory T Knipp
  • Organic Anion and Cation Drug Transporters / Takashi Sekine, Hiroyuki Kusuhara
  • Gastric Retentive Drug Delivery Systems / John R Cardinal, Avinash Nangia
  • Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems / Sravan Penchala, Anh-Nhan Pham, Ying Huang, Jeffrey Wang
  • Prodrug Strategies to Enhance Oral Drug Absorption / Sai H S Boddu, Deep Kwatra, Ashim K Mitra
  • Oral Delivery of Protein/Peptide Therapeutics / Puchun Liu, Steven Dinh
  • ABC Transporters in Intestinal and Liver Efflux / Marilyn E Morris, Yash A Gandhi
  • Interplay between Efflux Transporters and Metabolic Enzymes / Stephen Wang
  • Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions / Yuanchao (Derek) Zhang, Lei Zhang, John M Strong, Shiew-Mei Huang
  • Caco-2 Cell Culture Model for Oral Drug Absorption / Kaustubh Kulkarni, Ming Hu
  • MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption / Deep Kwatra, Sai H S Boddu, Ashim K Mitra
  • Intestinal Perfusion Methods for Oral Drug Absorptions / Wei Zhu, Eun Ju Jeong
  • Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion / Cindy Q Xia, Chuang Lu, Suresh K Balani
  • Methods for Oral Bioavailability Studies / Ana Ruiz-Garcia, Marival Bermejo
  • Determination of Regulation of Drug-Metabolizing Enzymes and Transporters / Bin Zhang, Wen Xie
  • Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction / Miguel Angel Cabrera-P̌rez, Isabel Gonzalez-alvarez
  • Index
  • Wiley Series in Drug Discovery and Development.