The physical foundation of protein architecture / Nobuhiko Saito, Yukio Kobayashi.
A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recove...
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Full Text (via ProQuest) |
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| Format: | eBook |
| Language: | English |
| Published: |
Singapore ; River Edge, N.J. :
World Scientific,
©2001.
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| Subjects: |
| Summary: | A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. The Physical Foundation of Protein Architecture is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed. |
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| Physical Description: | 1 online resource (ix, 144 pages) : illustrations. |
| Bibliography: | Includes bibliographical references (pages 135-142) and index. |
| ISBN: | 9789812811011 981281101X 1281956570 9781281956576 |