NMR spectroscopy in pharmaceutical analysis [electronic resource] / edited by Ulrike Holzgrabe, Iwona Wawer, Bernd Diehl.

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatograph...

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Bibliographic Details
Online Access: Full Text (via ScienceDirect)
Other Authors: Holzgrabe, U. (Ulrike), Wawer, I. (Iwona), Diehl, B. (Bernd)
Format: Electronic eBook
Language:English
Published: Oxford : Elsevier, 2008.
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Summary:For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. . combines theory, techniques, and concrete applications-all of which closely resemble the laboratory experience . considers international pharmacopoeias, addressing the concern for licensing . features the work of academics and researchers, appealing to a broad readership.
Physical Description:1 online resource (xxi, 501 pages) : illustrations.
Bibliography:Includes bibliographical references and index.
ISBN:9780444531735
0444531734
9780080558196
0080558194