Nuclear medicine technology progress report for quarter ending December 31, 1980 [electronic resource]
A method was developed for the synthesis of terminal haloalkyl (X-R)-substituted selenium (Se)- and tellurium (Te)-long-chain fatty acids. Several iodinated Se- and Te-fatty acids have now been prepared including the iodinated analog of methyl-9-THDA, methyl-17-iodo-9-telluraheptadecanoic acid (I-(C...
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Online Access (via OSTI) |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Oak Ridge, Tenn. : Oak Ridge, Tenn. :
Oak Ridge National Laboratory. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1981.
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| Subjects: |
MARC
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| 035 | |a (TOE)ost6539343 | ||
| 035 | |a (TOE)6539343 | ||
| 040 | |a TOE |c TOE | ||
| 049 | |a GDWR | ||
| 072 | 7 | |a 62 |2 edbsc | |
| 072 | 7 | |a 38 |2 edbsc | |
| 072 | 7 | |a 63 |2 edbsc | |
| 086 | 0 | |a E 1.99:ornl/tm-7685 | |
| 086 | 0 | |a E 1.99:ornl/tm-7685 | |
| 088 | |a ornl/tm-7685 | ||
| 245 | 0 | 0 | |a Nuclear medicine technology progress report for quarter ending December 31, 1980 |h [electronic resource] |
| 260 | |a Oak Ridge, Tenn. : |b Oak Ridge National Laboratory. ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1981. | ||
| 300 | |a Pages: 21 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 05/01/1981. | ||
| 500 | |a "ornl/tm-7685" | ||
| 500 | |a Knapp, F.F. Jr. | ||
| 520 | 3 | |a A method was developed for the synthesis of terminal haloalkyl (X-R)-substituted selenium (Se)- and tellurium (Te)-long-chain fatty acids. Several iodinated Se- and Te-fatty acids have now been prepared including the iodinated analog of methyl-9-THDA, methyl-17-iodo-9-telluraheptadecanoic acid (I-(CH/sub 2/)/sub 8/-Te-(CH/sub 2/)/sub 7/-COOCH/sub 3/). A principal goal is the preparation and biological evaluation of the /sup 123/I-labeled fatty acids. Osmium-191 was produced for the first time in the High Flux Isotope Reactor (HFIR) and supplied to collaborators for patient studies with the /sup 191m/Ir daughter obtained from the /sup 191/Os ..-->.. /sup 191m/Ir generator system. The /sup 191m/Ir is an excellent isotope for first-pass radionuclide angiographic evaluation of ventricular ejection fraction, intracardiac shunts, and a variety of other clinical applications. The factors affecting /sup 191/Os production are being investigated and improvements in the generator are in progress. In a new cooperative program, /sup 117m/Sn has been produced in the HFIR and supplied to investigators to investigate the mechanism of labeling of red blood cells (rbc) with /sup 117m/SnCl/sub 2/ for performing rbc volume measurements, and gated blood pool imaging studies. Labeling is efficient (70%), and the /sup 117m/Sn is strongly bound to the cells. The attractive emission properties and moderate physical half-life of /sup 117m/Sn suggest that /sup 117m/Sn-labeled rbc ejection fraction measurements could be very useful if high specific activity /sup 117m/Sn can be produced. Five production runs of /sup 11/C-labeled amino acids were made in conjunction with the Oak Ridge Associated Universities (ORAU). These agents were evaluated for tumor localization, pancreas imaging, and brain scanning in patients and included /sup 11/C-DL-valine, /sup 11/C-DL-tryptophan, and /sup 11/C-l-aminocyclobutanecarboxylic acid (/sup 11/C-ACBC). (ERB) | |
| 536 | |b W-7405-ENG-26. | ||
| 650 | 7 | |a Carboxylic Acid Esters. |2 local. | |
| 650 | 7 | |a Radiopharmaceuticals. |2 local. | |
| 650 | 7 | |a Iodine 123. |2 local. | |
| 650 | 7 | |a Chemical Preparation. |2 local. | |
| 650 | 7 | |a Iridium 191. |2 local. | |
| 650 | 7 | |a Diagnostic Uses. |2 local. | |
| 650 | 7 | |a Isotope Production. |2 local. | |
| 650 | 7 | |a Osmium 191. |2 local. | |
| 650 | 7 | |a Erythrocytes. |2 local. | |
| 650 | 7 | |a Labelling. |2 local. | |
| 650 | 7 | |a Tin 117. |2 local. | |
| 650 | 7 | |a Amino Acids. |2 local. | |
| 650 | 7 | |a Carbon 11. |2 local. | |
| 650 | 7 | |a Arsenic Oxides. |2 local. | |
| 650 | 7 | |a Toxicity. |2 local. | |
| 650 | 7 | |a Antineoplastic Drugs. |2 local. | |
| 650 | 7 | |a Evaluation. |2 local. | |
| 650 | 7 | |a Platinum 195. |2 local. | |
| 650 | 7 | |a Plutonium Compounds. |2 local. | |
| 650 | 7 | |a Actinide Compounds. |2 local. | |
| 650 | 7 | |a Arsenic Compounds. |2 local. | |
| 650 | 7 | |a Beta Decay Radioisotopes. |2 local. | |
| 650 | 7 | |a Beta-Minus Decay Radioisotopes. |2 local. | |
| 650 | 7 | |a Beta-Plus Decay Radioisotopes. |2 local. | |
| 650 | 7 | |a Biological Materials. |2 local. | |
| 650 | 7 | |a Blood. |2 local. | |
| 650 | 7 | |a Blood Cells. |2 local. | |
| 650 | 7 | |a Body Fluids. |2 local. | |
| 650 | 7 | |a Carbon Isotopes. |2 local. | |
| 650 | 7 | |a Carboxylic Acids. |2 local. | |
| 650 | 7 | |a Chalcogenides. |2 local. | |
| 650 | 7 | |a Days Living Radioisotopes. |2 local. | |
| 650 | 7 | |a Drugs. |2 local. | |
| 650 | 7 | |a Electron Capture Radioisotopes. |2 local. | |
| 650 | 7 | |a Enriched Uranium Reactors. |2 local. | |
| 650 | 7 | |a Esters. |2 local. | |
| 650 | 7 | |a Even-Odd Nuclei. |2 local. | |
| 650 | 7 | |a Heavy Nuclei. |2 local. | |
| 650 | 7 | |a Hours Living Radioisotopes. |2 local. | |
| 650 | 7 | |a Intermediate Mass Nuclei. |2 local. | |
| 650 | 7 | |a Internal Conversion Radioisotopes. |2 local. | |
| 650 | 7 | |a Iodine Isotopes. |2 local. | |
| 650 | 7 | |a Iridium Isotopes. |2 local. | |
| 650 | 7 | |a Irradiation Reactors. |2 local. | |
| 650 | 7 | |a Isomeric Transition Isotopes. |2 local. | |
| 650 | 7 | |a Isotope Production Reactors. |2 local. | |
| 650 | 7 | |a Isotopes. |2 local. | |
| 650 | 7 | |a Labelled Compounds. |2 local. | |
| 650 | 7 | |a Light Nuclei. |2 local. | |
| 650 | 7 | |a Materials. |2 local. | |
| 650 | 7 | |a Minutes Living Radioisotopes. |2 local. | |
| 650 | 7 | |a Nuclei. |2 local. | |
| 650 | 7 | |a Odd-Even Nuclei. |2 local. | |
| 650 | 7 | |a Organic Acids. |2 local. | |
| 650 | 7 | |a Organic Compounds. |2 local. | |
| 650 | 7 | |a Organic Halogen Compounds. |2 local. | |
| 650 | 7 | |a Osmium Isotopes. |2 local. | |
| 650 | 7 | |a Oxides. |2 local. | |
| 650 | 7 | |a Oxygen Compounds. |2 local. | |
| 650 | 7 | |a Platinum Isotopes. |2 local. | |
| 650 | 7 | |a Radioisotopes. |2 local. | |
| 650 | 7 | |a Reactors. |2 local. | |
| 650 | 7 | |a Research And Test Reactors. |2 local. | |
| 650 | 7 | |a Research Reactors. |2 local. | |
| 650 | 7 | |a Seconds Living Radioisotopes. |2 local. | |
| 650 | 7 | |a Stable Isotopes. |2 local. | |
| 650 | 7 | |a Synthesis. |2 local. | |
| 650 | 7 | |a Tank Type Reactors. |2 local. | |
| 650 | 7 | |a Test Reactors. |2 local. | |
| 650 | 7 | |a Therapy. |2 local. | |
| 650 | 7 | |a Thermal Reactors. |2 local. | |
| 650 | 7 | |a Tin Isotopes. |2 local. | |
| 650 | 7 | |a Transuranium Compounds. |2 local. | |
| 650 | 7 | |a Uses. |2 local. | |
| 650 | 7 | |a Water Cooled Reactors. |2 local. | |
| 650 | 7 | |a Water Moderated Reactors. |2 local. | |
| 650 | 7 | |a Radiology And Nuclear Medicine. |2 edbsc. | |
| 650 | 7 | |a Radiation Chemistry, Radiochemistry, And Nuclear Chemistry. |2 edbsc. | |
| 650 | 7 | |a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.. |2 edbsc. | |
| 710 | 2 | |a Oak Ridge National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
| 856 | 4 | 0 | |u http://www.osti.gov/scitech/biblio/6539343 |z Online Access (via OSTI) |
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