Nuclear medicine technology progress report for quarter ending December 31, 1980 [electronic resource]
A method was developed for the synthesis of terminal haloalkyl (X-R)-substituted selenium (Se)- and tellurium (Te)-long-chain fatty acids. Several iodinated Se- and Te-fatty acids have now been prepared including the iodinated analog of methyl-9-THDA, methyl-17-iodo-9-telluraheptadecanoic acid (I-(C...
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Online Access (via OSTI) |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Oak Ridge, Tenn. : Oak Ridge, Tenn. :
Oak Ridge National Laboratory. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1981.
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| Subjects: |
| Summary: | A method was developed for the synthesis of terminal haloalkyl (X-R)-substituted selenium (Se)- and tellurium (Te)-long-chain fatty acids. Several iodinated Se- and Te-fatty acids have now been prepared including the iodinated analog of methyl-9-THDA, methyl-17-iodo-9-telluraheptadecanoic acid (I-(CH/sub 2/)/sub 8/-Te-(CH/sub 2/)/sub 7/-COOCH/sub 3/). A principal goal is the preparation and biological evaluation of the /sup 123/I-labeled fatty acids. Osmium-191 was produced for the first time in the High Flux Isotope Reactor (HFIR) and supplied to collaborators for patient studies with the /sup 191m/Ir daughter obtained from the /sup 191/Os ..-->.. /sup 191m/Ir generator system. The /sup 191m/Ir is an excellent isotope for first-pass radionuclide angiographic evaluation of ventricular ejection fraction, intracardiac shunts, and a variety of other clinical applications. The factors affecting /sup 191/Os production are being investigated and improvements in the generator are in progress. In a new cooperative program, /sup 117m/Sn has been produced in the HFIR and supplied to investigators to investigate the mechanism of labeling of red blood cells (rbc) with /sup 117m/SnCl/sub 2/ for performing rbc volume measurements, and gated blood pool imaging studies. Labeling is efficient (70%), and the /sup 117m/Sn is strongly bound to the cells. The attractive emission properties and moderate physical half-life of /sup 117m/Sn suggest that /sup 117m/Sn-labeled rbc ejection fraction measurements could be very useful if high specific activity /sup 117m/Sn can be produced. Five production runs of /sup 11/C-labeled amino acids were made in conjunction with the Oak Ridge Associated Universities (ORAU). These agents were evaluated for tumor localization, pancreas imaging, and brain scanning in patients and included /sup 11/C-DL-valine, /sup 11/C-DL-tryptophan, and /sup 11/C-l-aminocyclobutanecarboxylic acid (/sup 11/C-ACBC). (ERB) |
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| Item Description: | Published through SciTech Connect. 05/01/1981. "ornl/tm-7685" Knapp, F.F. Jr. |
| Physical Description: | Pages: 21 : digital, PDF file. |