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150916s2015 caua foab 000 0 eng d |
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|a 9781615042296
|q electronic
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|a 10.4199/C00136ED1V01Y201507ISP064
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|a cdlls201507isp064
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|a (OCoLC)921272082
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|a (CaBNVSL)swl00405547
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|a CaBNVSL
|b eng
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|c CaBNVSL
|d CaBNVSL
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4 |
|a QP249
|b .E927 2015
|
| 100 |
1 |
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|a Evans, Louise C.,
|e author.
|0 http://id.loc.gov/authorities/names/n86846318
|1 http://isni.org/isni/000000003858011X.
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| 245 |
1 |
0 |
|a Renal medullary circulation /
|c Louise C. Evans and Allen W. Cowley Jr.
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| 264 |
|
1 |
|a San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
|b Morgan & Claypool,
|c 2015.
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| 300 |
|
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|a 1 PDF (viii, 96 pages) :
|b illustrations.
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| 336 |
|
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|a text
|b txt
|2 rdacontent.
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| 337 |
|
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|a electronic
|2 isbdmedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 490 |
1 |
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|a Colloquium series on integrated systems physiology,
|x 2154-5626 ;
|v # 64.
|
| 500 |
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|a Part of: Colloquium digital library of life sciences.
|
| 504 |
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|a Includes bibliographical references (pages 69-94)
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| 505 |
0 |
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|a 1. Introduction --
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| 505 |
8 |
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|a 2. Anatomy and ultrastructure -- 2.1 Vascular structures within the renal medulla -- 2.2 Structural organization of the outer medulla -- 2.3 Structural organization of the inner medulla --
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| 505 |
8 |
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|a 3. Functional roles of medullary blood flow -- 3.1 Countercurrent multiplication -- 3.2 Countercurrent exchange -- 3.3 Pressure natriuresis -- 3.4 Medullary blood flow and tissue oxygenation -- 3.5 Mathematical modeling of medullary function from medullary structure --
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| 505 |
8 |
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|a 4. Experimental assessment of medullary perfusion -- 4.1 Video microscopy -- 4.2 Measurement of medullary blood flow using laser-Doppler flowmetry -- 4.3 Ultrasound as a tool to assess medullary perfusion -- 4.4 Measurement of tissue oxygenation -- 4.5 Infusion of vasoactive compounds into the renal medulla -- 4.6 In vitro microperfusion of isolated microvessels --
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| 505 |
8 |
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|a 5. Pericytes and non-hormonal regulation of vasa recta tone -- 5.1 Pericytes -- 5.2 Mechanosensitive responses -- 5.3 Renal innervation --
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| 505 |
8 |
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|a 6. Hormonal regulation of vasa recta tone -- 6.1 Vasopressin -- 6.2 Angiotensin -- 6.3 Nitric oxide -- 6.4 Reactive oxygen species -- 6.5 Endothelin -- 6.6 Adrenomedullin -- 6.7 Adenosine -- 6.8 Arachadonic acid metabolites -- 6.9 Kinins --
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| 505 |
8 |
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|a 7. Reductions in medullary blood flow initiate hypertension --
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| 505 |
8 |
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|a 8. The Dahl salt-sensitive rat as a model of reduced medullary blood flow --
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| 505 |
8 |
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|a 9. Summary -- References -- Author biographies.
|
| 520 |
3 |
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|a The two kidneys of mammalian organisms receive around 25% of the cardiac output at rest, of which only 7% is distributed to the renal medulla. Despite the low blood flow to the renal medulla, small changes in perfusion to the region can have profound effects on urine-concentrating ability and the excretion of sodium, which in turn affects the chronic regulation of body fluid volumes and arterial blood pressure. Importantly, we know that if blood flow to the renal medulla is not tightly regulated, sodium and water homeostasis is impaired and medullary hypoxia develops. The resultant injury inevitably reduces urine concentrating ability and leads to hypertension. This book will discuss the variety of mechanisms that mammalian organisms have developed to ensure that renal medullary blood flow and oxygen levels are precisely regulated. This book will focus on the unique anatomical arrangement of the medullary circulation, the functional roles of medullary blood flow, as well as the experimental techniques used to assess medullary blood flow and the insight that these studies have provided. The hormonal and non-hormonal control of medullary blood flow will be considered and finally the impact of reduced medullary blood flow on blood pressure is discussed.
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| 538 |
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|a Mode of access: World Wide Web.
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| 538 |
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|a System requirements: Adobe Acrobat reader.
|
| 588 |
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|a Title from PDF title page (viewed on September 16, 2015)
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| 650 |
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0 |
|a Renal circulation.
|0 http://id.loc.gov/authorities/subjects/sh00008697
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| 700 |
1 |
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|a Cowley, Allen W.,
|c Jr.,
|e author.
|0 http://id.loc.gov/authorities/names/n84003129
|1 http://isni.org/isni/0000000063458992.
|
| 776 |
0 |
8 |
|i Print version:
|z 9781615042289.
|
| 856 |
4 |
8 |
|3 Abstract with links to full text
|u https://colorado.idm.oclc.org/login?url=http://dx.doi.org/10.4199/C00136ED1V01Y201507ISP064
|z Full Text (via Colloquium Digital Library)
|
| 830 |
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0 |
|a Colloquium series on integrated systems physiology ;
|v #64.
|0 http://id.loc.gov/authorities/names/no2010130952
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