Progress in molecular biology and translational science. Volume 87, Regulatory mechanisms in transcriptional signaling / edited by Debabrata Chakravarti.
Regulatory Mechanisms in Transcriptional Signaling, volume of Progress in Molecular Biology and Translational Science, includes in-depth discussion on roles of Chromatin remodeling proteins in nuclear receptor signaling, and ANCCA regulator in cancer. This important resource, edited by Dr. Debabrata...
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| Online Access: |
Full Text (via ScienceDirect) |
|---|---|
| Other Authors: | |
| Other title: | Regulatory mechanisms in transcriptional signaling. |
| Format: | eBook |
| Language: | English |
| Published: |
Amsterdam ; Boston :
Elsevier/Academic Press,
©2009.
|
| Series: | Progress in molecular biology and translational science ;
v. 87. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Progress in molecular biology and translational science. |n Volume 87, |p Regulatory mechanisms in transcriptional signaling / |c edited by Debabrata Chakravarti. |
| 246 | 3 | |a Regulatory mechanisms in transcriptional signaling. | |
| 260 | |a Amsterdam ; |a Boston : |b Elsevier/Academic Press, |c ©2009. | ||
| 300 | |a 1 online resource (xxii, 390 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 490 | 1 | |a Progress in molecular biology and translational science ; |v v. 87. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Progress in Molecular Biology and Translational Science; Copyright Page; Contents; Contributors; Preface; Introduction: Regulatory Mechanisms in Transcriptional Signaling by Nuclear Hormone Receptors, and their Regulators: Implications in Physiology and Disease; Acknowledgment; B. PPARgamma; C. LXR and Atherosclerosis; F. Therapeutic Potential of LXR Ligands; A. FXR and the Control of Bile Metabolism; E. FXR and Diabetes; G. Therapeutic Potential of FXR Ligands; V. RORalpha; E. Therapeutic Potential of ERRalpha Ligands. | |
| 505 | 8 | |a Chapter 2: Progesterone Receptor Action in Leiomyoma and Endometrial CancerB. Progesterone Receptors; D. Progesterone Receptors in the Endometrium and Myometrium; B. Progesterone Receptors in Endometrial Cancer; C. Growth Factor Regulation in Leiomyoma by Progesterone; IX. Conclusions and Perspectives on Progesterone Action in Uterine Leiomyoma; I. Introduction; 1. PXR in UGT Regulation; 2. PXR in SULT Regulation; 3. PXR in GST Regulation; 1. PXR in Bile Acid Detoxification and Cholestasis; 2. PXR in Bilirubin Detoxification and Clearance. | |
| 505 | 8 | |a 3. PXR in Adrenal Steroid Homeostasis and Drug-Hormone Interactions4. PXR in Lipid Metabolism; G. Species Specificity of PXR and the Creation of ̀̀Humanized ́ ́ Mice; 1. Challenges for Rodents as Drug Metabolism Models; 2. Species Specificity of the Rodent and hPXR; 3. Creation and Characterization of the hPXR ''Humanized'' Mice; 4. Significance of Humanized Mice in Drug Metabolism Studies and Drug Development; 1. CAR Regulation of CYP2C Genes; 2. CAR Regulation of UGT1A1 Genes; 3. CAR Regulation of Drug Transporters; Acknowledgments. | |
| 505 | 8 | |a A. Nuclear Receptor Protein Stability, Targeting by the Ubiquitin Proteasome System and Influences of Ligand on Nuclear Receptor Protein DegradationB. Role of the Ubiquitin Proteasome System in Nuclear Receptor-Mediated Transcription; II. Biochemical Analyses of NR Activities, Interactions, and Functions: An Historical View; A. Elucidation of NR Biochemical Activities; D. Transcriptional Regulation by NRs: Early Studies; III. Role of Chromatin in NR-Dependent Transcription; A. Chromatin: The Physiological Template for NR-Dependent Transcription; B. Linking NR Function to Chromatin. | |
| 505 | 8 | |a B. DNA TemplatesC. Methods for Assembling Chromatin In Vitro; 1. Salt Dilution/Dialysis Chromatin Assembly Systems; 2. Extract-Based Chromatin Assembly Systems; 3. Defined Chromatin Assembly Systems; 1. Nuclease Digestion of Chromatin Assembled In Vitro; 2. Analysis of the Physical Properties of Chromatin Assembled in vitro; 3. Imaging of Chromatin Assembled in vitro; A. Role of Ligands; 1. Agonist Ligands are Required for NR-Dependent Transcription with Chromatin Templates; 2. Agonist Ligands Promote Productive Interactions with NR Coregulators; 1. p160/SRC Proteins. | |
| 520 | |a Regulatory Mechanisms in Transcriptional Signaling, volume of Progress in Molecular Biology and Translational Science, includes in-depth discussion on roles of Chromatin remodeling proteins in nuclear receptor signaling, and ANCCA regulator in cancer. This important resource, edited by Dr. Debabrata (Debu) Chakravarti, offers research on the progesterone receptor action in leiomyoma and endometrial cancer and emerging roles of the ubiquitin protein system in nuclear hormone receptor signaling, in order to provide the reader with expert discussions of up-to-date research. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Genetic transcription |x Regulation. | |
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| 650 | 7 | |a Genetic transcription |x Regulation. |2 fast |0 (OCoLC)fst00940102. | |
| 700 | 1 | |a Chakravarti, Debabrata. | |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v v. 87. | |
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