Target validation in drug discovery [electronic resource] / editors, Brian W. Metcalf and Susan Dillon.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...
Saved in:
| Online Access: |
Full Text (via ScienceDirect) |
|---|---|
| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Amsterdam ; Boston :
Academic Press,
©2007.
|
| Subjects: |
MARC
| LEADER | 00000cam a2200000xa 4500 | ||
|---|---|---|---|
| 001 | b8580310 | ||
| 003 | CoU | ||
| 005 | 20220513050510.0 | ||
| 006 | m o d | ||
| 007 | cr ||||||||||| | ||
| 008 | 070802s2007 enka ob 001 0 eng d | ||
| 019 | |a 730500505 |a 1055395150 |a 1062921691 |a 1081276599 | ||
| 020 | |a 9780123693938 | ||
| 020 | |a 0123693934 | ||
| 020 | |a 9780080465975 |q (electronic bk.) | ||
| 020 | |a 0080465978 |q (electronic bk.) | ||
| 035 | |a (OCoLC)scd162130366 | ||
| 035 | |a (OCoLC)162130366 |z (OCoLC)730500505 |z (OCoLC)1055395150 |z (OCoLC)1062921691 |z (OCoLC)1081276599 | ||
| 037 | |a scd9780123693938 | ||
| 040 | |a OPELS |b eng |e pn |c OPELS |d OCLCG |d OCLCQ |d N$T |d OCLCQ |d OCLCF |d OCLCQ |d CHVBK |d NLGGC |d YDXCP |d OCLCQ |d TOA |d AGLDB |d OCLCO |d JBG |d VNS |d OCLCO |d D6H |d OCLCO |d OCLCQ |d VTS |d REC |d VT2 |d OCLCO |d OCLCQ |d WYU |d OCLCA |d S9I |d STF |d OCLCO |d LEAUB |d OCLCO |d M8D |d OCLCO |d OCLCA |d OCLCO |d OCLCQ | ||
| 049 | |a GWRE | ||
| 050 | 4 | |a RM301.63 |b .T36 2007eb | |
| 245 | 0 | 0 | |a Target validation in drug discovery |h [electronic resource] / |c editors, Brian W. Metcalf and Susan Dillon. |
| 260 | |a Amsterdam ; |a Boston : |b Academic Press, |c ©2007. | ||
| 300 | |a 1 online resource (xii, 279 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 347 | |a data file. | ||
| 505 | 0 | |a Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Drug development. |0 http://id.loc.gov/authorities/subjects/sh97007921. | |
| 650 | 0 | |a Drugs |x Testing. |0 http://id.loc.gov/authorities/subjects/sh85039755. | |
| 650 | 0 | |a High throughput screening (Drug development) |0 http://id.loc.gov/authorities/subjects/sh2001002949. | |
| 650 | 0 | |a Drugs |x Design. |0 http://id.loc.gov/authorities/subjects/sh88001157. | |
| 650 | 0 | |a Pharmaceutical technology. |0 http://id.loc.gov/authorities/subjects/sh85100590. | |
| 650 | 7 | |a Drug development. |2 fast |0 (OCoLC)fst00898670. | |
| 650 | 7 | |a Drugs |x Testing. |2 fast |0 (OCoLC)fst00898940. | |
| 650 | 7 | |a High throughput screening (Drug development) |2 fast |0 (OCoLC)fst00956496. | |
| 700 | 1 | |a Metcalf, Brian W. |0 http://id.loc.gov/authorities/names/n94801986 |1 http://isni.org/isni/0000000035197705. | |
| 700 | 1 | |a Dillon, Susan, |d 1952- |0 http://id.loc.gov/authorities/names/n2006058857 |1 http://isni.org/isni/0000000383116617. | |
| 776 | 0 | 8 | |i Print version: |t Target validation in drug discovery. |d Amsterdam ; Boston : Academic Press, ©2007 |z 0123693934 |z 9780123693938 |w (DLC) 2006049868 |w (OCoLC)70823305. |
| 856 | 4 | 0 | |u https://colorado.idm.oclc.org/login?url=https://www.sciencedirect.com/science/book/9780123693938 |z Full Text (via ScienceDirect) |
| 907 | |a .b85803108 |b 06-06-22 |c 05-10-16 | ||
| 998 | |a web |b 05-31-22 |c b |d b |e - |f eng |g enk |h 0 |i 1 | ||
| 907 | |a .b85803108 |b 06-01-22 |c 05-10-16 | ||
| 944 | |a MARS - RDA ENRICHED | ||
| 956 | |a ScienceDirect All Books | ||
| 915 | |a - | ||
| 956 | |b ScienceDirect All Books | ||
| 956 | |a ScienceDirect ebooks | ||
| 999 | f | f | |i 523c8c60-ba40-5b9f-b03c-5fc158d0dd49 |s 2ec0264b-4ec6-5798-9ad8-e61ace7346ac |
| 952 | f | f | |p Can circulate |a University of Colorado Boulder |b Online |c Online |d Online |e RM301.63 .T36 2007eb |h Library of Congress classification |i web |n 1 |