Target validation in drug discovery [electronic resource] / editors, Brian W. Metcalf and Susan Dillon.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...
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| Online Access: |
Full Text (via ScienceDirect) |
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Amsterdam ; Boston :
Academic Press,
©2007.
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| Subjects: |
| Summary: | This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book. |
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| Physical Description: | 1 online resource (xii, 279 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9780123693938 0123693934 9780080465975 0080465978 |