The one-stage prothrombin time: Alterations due to changes in pH / Jarrell D. Bairrington, Emil W. Peterson.
The study involved the relationship of Factor V lability due to pH to pH variations in the performance of the one-stage prothrombin time. Samples of blood were drawn from ten patients on long-term, coumarin-derivative therapy. The pH of each sample was decreased progressively from 7.79 to 6.05 with...
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| Main Author: | |
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| Corporate Author: | |
| Other Authors: | |
| Format: | Government Document Book |
| Language: | English |
| Published: |
Brooks Air Force Base, TX :
USAF School of Aerospace Medicine - Aerospace Medical Division (AFSC),
1967.
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| Series: | SAM-TR ;
67-76. |
| Subjects: |
MARC
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| 088 | |a USAF SAM TR 67-76 | ||
| 100 | 1 | |a Bairrington, Jarrell D. | |
| 245 | 1 | 4 | |a The one-stage prothrombin time: Alterations due to changes in pH / |c Jarrell D. Bairrington, Emil W. Peterson. |
| 260 | |a Brooks Air Force Base, TX : |b USAF School of Aerospace Medicine - Aerospace Medical Division (AFSC), |c 1967. | ||
| 300 | |a iii, 9 pages : |b illustrations ; |c 27 cm. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a unmediated |b n |2 rdamedia. | ||
| 338 | |a volume |b nc |2 rdacarrier. | ||
| 490 | 1 | |a SAM-TR ; |v 67-76. | |
| 500 | |a "August 1967." | ||
| 504 | |a Includes bibliographical references. | ||
| 520 | 3 | |a The study involved the relationship of Factor V lability due to pH to pH variations in the performance of the one-stage prothrombin time. Samples of blood were drawn from ten patients on long-term, coumarin-derivative therapy. The pH of each sample was decreased progressively from 7.79 to 6.05 with lactic acid and the prothrombin time was determined. Each sample was then incubated for 4 hours at 37 degrees C and the pH and prothrombin time were measured again on each sample. Factor V activity and lactic acid were added to the samples in varying order. The addition of lactic acid after incubation did not alter the prothrombin time. The addition of Factor V activity without changing the pH brought the prothrombin time to values less than at pre-incubation time. The optimal pH for maximal enzyme activity and the mechanism for Factor V lability in the incubated plasma are briefly discussed. | |
| 650 | 0 | |a Blood coagulation factors. |0 http://id.loc.gov/authorities/subjects/sh85014975. | |
| 650 | 0 | |a Blood |x Coagulation. |0 http://id.loc.gov/authorities/subjects/sh85014936. | |
| 650 | 0 | |a Prothrombin. |0 http://id.loc.gov/authorities/subjects/sh85107736. | |
| 650 | 0 | |a Hydrogen-ion concentration. |0 http://id.loc.gov/authorities/subjects/sh85063427. | |
| 650 | 7 | |a Blood |x Coagulation. |2 fast |0 (OCoLC)fst00834568. | |
| 650 | 7 | |a Blood coagulation factors. |2 fast |0 (OCoLC)fst00834710. | |
| 650 | 7 | |a Hydrogen-ion concentration. |2 fast |0 (OCoLC)fst00965064. | |
| 650 | 7 | |a Prothrombin. |2 fast |0 (OCoLC)fst01079971. | |
| 700 | 1 | |a Peterson, Emil W. | |
| 710 | 2 | |a USAF School of Aerospace Medicine. |0 http://id.loc.gov/authorities/names/n79120293 |1 http://isni.org/isni/0000000094055889. | |
| 830 | 0 | |a SAM-TR ; |v 67-76. | |
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| 952 | f | f | |p Can circulate |a University of Colorado Boulder |b Boulder Campus |c Norlin |d Norlin Library - Government Information - US |e D 301.26/13-6:67-76 |h Superintendent of Documents classification |i document |m U183070994033 |n 1 |