Systems biology of Alzheimer's disease / edited by Juan I. Castrillo, Stephen G. Oliver.
"Alzheimer's disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental...
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| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
New York :
Humana Press,
[2016]
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| Series: | Methods in molecular biology (Clifton, N.J.) ;
v. 1303. Springer protocols (Series) |
| Subjects: |
Table of Contents:
- Alzheimer's as a systems-level disease involving the interplay of multiple cellular networks / Juan I. Castrillo and Stephen G. Oliver
- Application of systems theory in longitudinal studies on the origin and progression of Alzheimer's disease / Simone Lista ... [and others]
- APP proteolytic system and its interactions with dynamic networks in Alzheimer's disease / Sally Hunter, Steven Martin, and Carol Brayne
- Effects of mild and severe oxidative stress on BACE1 expression and APP amyloidogenic processing / Jiangli Tan, Qiao-Xin Li, and Genevieve Evin
- Advanced assay monitoring APP-carboxyl-terminal fragments as markers of APP processing in Alzheimer disease mouse models / Ana García-Osta and Mar Cuadrado-Tejedor
- Optical super-resolution imaging of [beta]-amyloid aggregation in vitro and in vivo : method and techniques / Dorothea Pinotsi, Gabriele S. Kaminski Schierle, and Clemens F. Kaminski
- Protocols for monitoring the development of Tau pathology in Alzheimer's disease / Alberto Rábano ... [and others]
- LC3-II tagging and western blotting for monitoring autophagic activity in mammalian cells / Anne Streeter, Fiona M. Menzies, and David C. Rubinsztein
- Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer's disease / Amandine Grimm, Karen Schmitt, and Anne Eckert
- Analysis of microglial proliferation in Alzheimer's disease / Diego Gomez-Nicola and V. Hugh Perry
- Yeast as a model for Alzheimer's disease : latest studies and advanced strategies / Mathias Verduyckt ... [and others]
- Yeast as a model for studies on A[beta] aggregation toxicity in Alzheimer's disease, autophagic responses, and drug screening / Afsaneh Porzoor and Ian Macreadie
- Drosophila melanogaster as a model for studies on the early stages of Alzheimer's disease / Jung Yeon Lim, Stanislav Ott, and Damian C. Crowther
- Chronic mild stress assay leading to early onset and propagation of Alzheimer's disease phenotype in mouse models / Mar Cuadrado-Tejedor and Ana García-Osta
- Gene expression studies on human trisomy 21 iPSCs and neurons : towards mechanisms underlying Down's syndrome and early Alzheimer's disease-like pathologies / Jason P. Weick, Huining Kang, George F. Bonadurer III, and Anita Bhattacharyya
- Cortical differentiation of human pluripotent cells for in vitro modeling of Alzheimer's disease / Nathalie G. Saurat, Frederick J. Livesey, and Steven Moore
- Next generation sequencing in Alzheimer's disease / Lars Bertram
- Pooled-DNA sequencing for elucidating new genomic risk factors, rare variants underlying Alzheimer's disease / Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, and Carlos Cruchaga
- New genome-wide methods for elucidation of candidate copy number variations (CNVs) contributing to Alzheimer's disease heritability / Kinga Szigeti
- RNA-sequencing to elucidate early patterns of dysregulation underlying the onset of Alzheimer's disease / Bei Jun Chen, James D. Mills, Caroline Janitz, and Michael Janitz
- Systems biology approaches to the study of biological networks underlying Alzheimer's disease : role of miRNAs / Wera Roth, David Hecker, and Eugenio Fava
- Emerging role of metalloproteomics in Alzheimer's disease research / Dominic J. Hare, Alan Rembach, and Blaine R. Roberts
- Redox proteomics in human biofluids : sample preparation, separation and immunochemical tagging for analysis of protein oxidation / Fabio Di Domenico, Marzia Perluigi, and D. Allan Butterfield
- Advanced shotgun lipidomics for characterization of altered lipid patterns in neurodegenerative diseases and brain injury / Miao Wang and Xianlin Han
- AlzPathway, an updated map of curated signaling pathways : towards deciphering Alzheimer's disease pathogenesis / Soichi Ogishima ... [and others]
- Computational network biology approach to uncover novel genes related to Alzheimer's disease / Andreas Zanzoni
- Network approaches to the understanding of Alzheimer's disease : from model organisms to humans / Justin Yerbury, Dan Bean, and Giorgio Favrin
- Characterization of genetic networks associated with Alzheimer's disease / Bin Zhang, Linh Tran, Valur Emilsson, and Jun Zhu
- Network-based analysis for uncovering mechanisms underlying Alzheimer's disease / Masataka Kikuchi ... [and others]
- SDREM method for reconstructing signaling and regulatory response networks : applications for studying disease progression / Anthony Gitter and Ziv Bar-Joseph
- Advanced neuroimaging methods towards characterization of early stages of Alzheimer's disease / Jorge Sepulcre and Joseph C. Masdeu
- Plasma proteomics biomarkers in Alzheimer's disease : latest advances and challenges / Robert Perneczky and Liang-Hao Guo
- Practical guide for exploring opportunities of repurposing drugs for CNS diseases in systems biology / Hongkang Mei ... [and others]