Fragment-based drug discovery /

Fragment-based drug discovery / edited by Steven Howard, Chris Abell.

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Bibliographic Details
Other Authors: Howard, Steven, PhD (Editor), Abell, C. (Editor)
Format: Book
Language:English
Published: Cambridge : Royal Society of Chemistry, [2015]
Series:RSC drug discovery series ; 47.
Subjects:
Drug development.
Ligands (Biochemistry)
Table of Contents:
  • ch. 1 Different Flavours of Fragments / Claudio Dagostin
  • 1.1.Fragment-Based Drug Discovery
  • 1.2.Different Types of Fragments
  • 1.3.How We Identify Fragments
  • 1.4.Selectivity
  • 1.5.Applications of Fragment-Based Methods
  • 1.5.1.Assigning Function
  • 1.5.2.Assessing Ligandability
  • 1.5.3.Speeding Up Chemical Validation
  • 1.6.Targeting Protein
  • Protein Interactions and Beyond
  • 1.7.Targeting Oligonucleotides
  • 1.8.Concluding Remarks
  • References
  • ch. 2 Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support / Brandon J. Bravo
  • 2.1.Introduction
  • 2.2.SPR Technology as Applied to FBS
  • 2.3.The Basic Screening Cascade
  • 2.4.Advances in Data Reduction and Active Selection in Primary Screening
  • 2.4.1.Robust Drift Correction by Local Estimation
  • 2.4.2.Method #1 for Hit Detection: Box Plots

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