Induction of mutation and differentiation in mammalian cells by chemicals which initiate or promote tumor formation [electronic resource]
A cell-mediated mutagenesis assay was developed to predict the potential carcinogenic hazard of some environmental chemicals. In this assay, cells with appropriate markers for mutagenesis, such as the Chinese hamster V79 cells, are co-cultivated with cells capable of metabolizing chemical carcinogen...
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Online Access |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1980.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Induction of mutation and differentiation in mammalian cells by chemicals which initiate or promote tumor formation |h [electronic resource] |
| 260 | |a Washington, D.C. : |b United States. Department of Energy. ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1980. | ||
| 300 | |a Pages: 13 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
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| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 01/01/1980. | ||
| 500 | |a "conf-800742--1" | ||
| 500 | |a 2. international congress on toxicology, Brussels, Belgium, 6 Jul 1980. | ||
| 500 | |a Huberman, E. | ||
| 520 | 3 | |a A cell-mediated mutagenesis assay was developed to predict the potential carcinogenic hazard of some environmental chemicals. In this assay, cells with appropriate markers for mutagenesis, such as the Chinese hamster V79 cells, are co-cultivated with cells capable of metabolizing chemical carcinogens. Use of this assay made it possible to demonstrate a relationship between the degree of carcinogenicity and mutagenicity of a series of polycyclic hydrocarbons, nitrosamines and aflatoxins, and to establish means to study organ specificity of some chemical carcinogens. However, most short term in vitro assays are designed to detect mutagenic activity and therefore do not detect tumor promoting agents which are devoid of this activity. By analyzing various markers of terminal differentiation in cultured human melanoma and myeloid leukemia cells, we have established a relationship between the activity of a series of tumor promoting phorbol diesters in the mouse skin and their ability to induce terminal differentiation. We suggest that measuring alterations in the differentiation characteristics of some cultured cells may represent an approach by which environmental tumor promoting agents can be studied and detected. | |
| 536 | |b W-7405-ENG-26. | ||
| 650 | 7 | |a Carcinogens. |2 local. | |
| 650 | 7 | |a Mutagen Screening. |2 local. | |
| 650 | 7 | |a Aflatoxin. |2 local. | |
| 650 | 7 | |a Animal Cells. |2 local. | |
| 650 | 7 | |a Bioassay. |2 local. | |
| 650 | 7 | |a Cell Cultures. |2 local. | |
| 650 | 7 | |a Cell Differentiation. |2 local. | |
| 650 | 7 | |a Hamsters. |2 local. | |
| 650 | 7 | |a Nitroso Compounds. |2 local. | |
| 650 | 7 | |a Polycyclic Aromatic Hydrocarbons. |2 local. | |
| 650 | 7 | |a Animals. |2 local. | |
| 650 | 7 | |a Aromatics. |2 local. | |
| 650 | 7 | |a Hydrocarbons. |2 local. | |
| 650 | 7 | |a Mammals. |2 local. | |
| 650 | 7 | |a Organic Compounds. |2 local. | |
| 650 | 7 | |a Organic Nitrogen Compounds. |2 local. | |
| 650 | 7 | |a Rodents. |2 local. | |
| 650 | 7 | |a Screening. |2 local. | |
| 650 | 7 | |a Vertebrates. |2 local. | |
| 650 | 7 | |a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.. |2 edbsc. | |
| 710 | 2 | |a Oak Ridge National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |4 spn. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
| 856 | 4 | 0 | |u http://www.osti.gov/servlets/purl/5338501/ |z Online Access |
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| 952 | f | f | |p Can circulate |a University of Colorado Boulder |b Online |c Online |d Online |e E 1.99:conf-800742--1 |h Superintendent of Documents classification |i web |n 1 |