A Phase 1 trial of intravenous boronophenylalanine-fructose complex in patients with glioblastoma multiforme

A Phase 1 trial of intravenous boronophenylalanine-fructose complex in patients with glioblastoma multiforme [electronic resource]

Boron neutron capture therapy (BNCT) of glioblastoma multiforme was initially performed at the Brookhaven National Laboratory in the early 1950̀s While this treatment for malignant brain tumors has continued in Japan, new worldwide interest has been stimulated by the development of new and more sele...

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Bibliographic Details
Online Access: Online Access
Corporate Author: Brookhaven National Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 1996.
Subjects:
Neutron Capture Therapy.
Brain.
Blood-brain Barrier.
Boron Compounds.
Neoplasms.
Therapeutic Uses.
Biology And Medicine, Basic Studies.

MARC

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245 0 2 |a A Phase 1 trial of intravenous boronophenylalanine-fructose complex in patients with glioblastoma multiforme  |h [electronic resource] 
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500 |a 6. international symposium on neutron capture therapy for cancer, Kobe (Japan), 31 Oct - 4 Nov 1994. 
500 |a Chadha, M.; Joel, D.; Bergland, R.; Elowitz, E.; Coderre, J.A. 
520 3 |a Boron neutron capture therapy (BNCT) of glioblastoma multiforme was initially performed at the Brookhaven National Laboratory in the early 1950̀s While this treatment for malignant brain tumors has continued in Japan, new worldwide interest has been stimulated by the development of new and more selective boron compounds. Boronophenylalanine (BPA) is a blood-brain barrier penetrating compound that has been used in BNCT of malignant melanomas. SPA has been employed experimentally in BNCT of rat gliosarcoma and has potential use in the treatment of human glioblastoma. As a preface to clinical BNCT trials, we studied the biodistribution of SPA in patients with glioblastoma. 
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