Sequential experimentation in clinical trials [electronic resource] : design and analysis / Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih.
This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequenti...
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Full Text (via Springer) |
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Springer,
©2013.
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| Series: | Springer series in statistics ;
298. |
| Subjects: |
Table of Contents:
- Introduction
- Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
- Sequential Testing Theory and Stochastic Optimization Over Time
- Group Sequential Design of Phase II and III Trials
- Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
- Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
- Confidence Intervals and p-Values
- Adaptive Design of Confirmatory Trials.