Rationale for nonlinear dose response functions of power greater or less than one. [Relation of multiple stresses to effects of low-dose irradiation in man] [electronic resource]
Risk estimates and radiation protection standards are generally made using a nonthreshold premise and linear extrapolations from existing data to estimate biological radiation effects at lower doses and at lower dose rates. This seems reasonable in light of the variety of shapes of dose-effect relat...
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| Online Access: |
Online Access |
|---|---|
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Oak Ridge, Tenn. :
distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1977.
|
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Rationale for nonlinear dose response functions of power greater or less than one. [Relation of multiple stresses to effects of low-dose irradiation in man] |h [electronic resource] |
| 260 | |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1977. | ||
| 300 | |a Pages: 8 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 08/01/1977. | ||
| 500 | |a "bnl-23150" | ||
| 500 | |a " conf-770663-1" | ||
| 500 | |a Workshop on repair mechanisms and exposure standards, Oak Ridge, Tennessee, USA, 28 Jun 1977. | ||
| 500 | |a Baum, J.W. | ||
| 500 | |a Brookhaven National Lab., Upton, N.Y. (USA) | ||
| 520 | 3 | |a Risk estimates and radiation protection standards are generally made using a nonthreshold premise and linear extrapolations from existing data to estimate biological radiation effects at lower doses and at lower dose rates. This seems reasonable in light of the variety of shapes of dose-effect relations which have been observed both in animal studies and in human epidemiological studies. An unexplained observation in several studies was a response which followed a power function of dose with exponent less than one. One explanation offered for this type of response in humans was a postulated population of heterogeneous sensitivity. An alternate, though related, way of considering this question is in terms of multiple-stresses, and this postulate is discussed. | |
| 536 | |b EY-76-C-02-0016. | ||
| 650 | 7 | |a Biological Stress. |2 local. | |
| 650 | 7 | |a Man. |2 local. | |
| 650 | 7 | |a Biological Radiation Effects. |2 local. | |
| 650 | 7 | |a Low Dose Irradiation. |2 local. | |
| 650 | 7 | |a Age Dependence. |2 local. | |
| 650 | 7 | |a Radiosensitivity Effects. |2 local. | |
| 650 | 7 | |a Environment. |2 local. | |
| 650 | 7 | |a Genetic Variability. |2 local. | |
| 650 | 7 | |a Human Populations. |2 local. | |
| 650 | 7 | |a Response Modifying Factors. |2 local. | |
| 650 | 7 | |a Animals. |2 local. | |
| 650 | 7 | |a Biological Effects. |2 local. | |
| 650 | 7 | |a Biological Variability. |2 local. | |
| 650 | 7 | |a Irradiation. |2 local. | |
| 650 | 7 | |a Mammals. |2 local. | |
| 650 | 7 | |a Dose-Response Relationships. |2 local. | |
| 650 | 7 | |a Populations. |2 local. | |
| 650 | 7 | |a Primates. |2 local. | |
| 650 | 7 | |a Radiation Effects. |2 local. | |
| 650 | 7 | |a Vertebrates. |2 local. | |
| 650 | 7 | |a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.. |2 edbsc. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
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