Microdialysis in drug development [electronic resource] / Markus Müller, editor.
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical...
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| Format: | Electronic eBook |
| Language: | English |
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New York, NY :
Springer,
©2013.
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| Series: | AAPS advances in the pharmaceutical sciences series ;
v. 4. |
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Table of Contents:
- Part 1. General Aspects
- Introduction to the Microdialysis Technology / Markus Müller
- Recovery and Calibration Techniques: Toward Quantitative Microdialysis / Elizabeth C.M. de Lange
- Analytical Considerations for Microdialysis Sampling / Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi and Susan M. Lunte, et al.
- Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / Chinmay Shukla, Jing Li, Robert Lionberger and Edward D. Bashaw.
- Part 2. Specific topics
- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / Margareta Hammarlund-Udenaes
- Microdialysis in Antibiotic Research / Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth and Hartmut Derendorf
- Skin and Transdermal Drug Delivery / Advantages and Challenges / Eva Benfeldt
- Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / Elizabeth de Lange
- Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / John R. Cirrito
- Microdialysis in Pain Research / Martin Brunner
- Microdialysis in Ocular Drug Development / Mitesh R. Patel, Nanda K. Mandava and Ashim K. Mitra
- Microdialysis in Metabolic Research / Per-Anders Jansson
- High Molecular Weight Targets and Treatments Using Microdialysis / Geraldine F. Clough, Julie A. Stenken and Martin K. Church
- Complementary Techniques: Positron Emission Tomography / Oliver Langer
- Open Flow Microperfusion: An Alternative Method to Microdialysis? / Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer and Selma Mautner, et al.
- Microdialysis in Internal Organs and Tumors / Robert Sauermann and Markus Zeitlinger.