Microdialysis in drug development [electronic resource] / Markus Müller, editor.

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Müller, Markus, 1967 August 23-
Format: Electronic eBook
Language:English
Published: New York, NY : Springer, ©2013.
Series:AAPS advances in the pharmaceutical sciences series ; v. 4.
Subjects:
Table of Contents:
  • Part 1. General Aspects
  • Introduction to the Microdialysis Technology / Markus Müller
  • Recovery and Calibration Techniques: Toward Quantitative Microdialysis / Elizabeth C.M. de Lange
  • Analytical Considerations for Microdialysis Sampling / Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi and Susan M. Lunte, et al.
  • Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / Chinmay Shukla, Jing Li, Robert Lionberger and Edward D. Bashaw.
  • Part 2. Specific topics
  • Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / Margareta Hammarlund-Udenaes
  • Microdialysis in Antibiotic Research / Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth and Hartmut Derendorf
  • Skin and Transdermal Drug Delivery / Advantages and Challenges / Eva Benfeldt
  • Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / Elizabeth de Lange
  • Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / John R. Cirrito
  • Microdialysis in Pain Research / Martin Brunner
  • Microdialysis in Ocular Drug Development / Mitesh R. Patel, Nanda K. Mandava and Ashim K. Mitra
  • Microdialysis in Metabolic Research / Per-Anders Jansson
  • High Molecular Weight Targets and Treatments Using Microdialysis / Geraldine F. Clough, Julie A. Stenken and Martin K. Church
  • Complementary Techniques: Positron Emission Tomography / Oliver Langer
  • Open Flow Microperfusion: An Alternative Method to Microdialysis? / Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer and Selma Mautner, et al.
  • Microdialysis in Internal Organs and Tumors / Robert Sauermann and Markus Zeitlinger.