Microdialysis in drug development [electronic resource] / Markus Müller, editor.
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical...
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Full Text (via Springer) |
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Springer,
©2013.
|
| Series: | AAPS advances in the pharmaceutical sciences series ;
v. 4. |
| Subjects: |
MARC
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| 300 | |a 1 online resource : |b color illustrations. | ||
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| 490 | 1 | |a AAPS advances in the pharmaceutical sciences series, |x 2210-7371 ; |v 4. | |
| 505 | 0 | 0 | |g Part 1. General Aspects -- |t Introduction to the Microdialysis Technology / |r Markus Müller -- |t Recovery and Calibration Techniques: Toward Quantitative Microdialysis / |r Elizabeth C.M. de Lange -- |t Analytical Considerations for Microdialysis Sampling / |r Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi and Susan M. Lunte, et al. -- |t Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / |r Chinmay Shukla, Jing Li, Robert Lionberger and Edward D. Bashaw. |
| 505 | 8 | 0 | |g Part 2. |t Specific topics -- |t Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / |r Margareta Hammarlund-Udenaes -- |t Microdialysis in Antibiotic Research / |r Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth and Hartmut Derendorf -- |t Skin and Transdermal Drug Delivery / |r Advantages and Challenges / |r Eva Benfeldt -- |t Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / |r Elizabeth de Lange -- |t Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / |r John R. Cirrito -- |t Microdialysis in Pain Research / |r Martin Brunner -- |t Microdialysis in Ocular Drug Development / |r Mitesh R. Patel, Nanda K. Mandava and Ashim K. Mitra -- |t Microdialysis in Metabolic Research / |r Per-Anders Jansson -- |t High Molecular Weight Targets and Treatments Using Microdialysis / |r Geraldine F. Clough, Julie A. Stenken and Martin K. Church -- |t Complementary Techniques: Positron Emission Tomography / |r Oliver Langer -- |t Open Flow Microperfusion: An Alternative Method to Microdialysis? / |r Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer and Selma Mautner, et al. -- |t Microdialysis in Internal Organs and Tumors / |r Robert Sauermann and Markus Zeitlinger. |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development. | ||
| 650 | 0 | |a Drug development. |0 http://id.loc.gov/authorities/subjects/sh97007921. | |
| 650 | 0 | |a Dialysis. |0 http://id.loc.gov/authorities/subjects/sh85037540. | |
| 650 | 0 | |a Drugs |x Bioavailability. |0 http://id.loc.gov/authorities/subjects/sh85039723. | |
| 650 | 7 | |a Dialysis. |2 fast |0 (OCoLC)fst00892536. | |
| 650 | 7 | |a Drug development. |2 fast |0 (OCoLC)fst00898670. | |
| 650 | 7 | |a Drugs |x Bioavailability. |2 fast |0 (OCoLC)fst00898775. | |
| 700 | 1 | |a Müller, Markus, |d 1967 August 23- |0 http://id.loc.gov/authorities/names/no2011064716. | |
| 830 | 0 | |a AAPS advances in the pharmaceutical sciences series ; |v v. 4. |0 http://id.loc.gov/authorities/names/n2011180825. | |
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