Microdialysis in drug development [electronic resource] / Markus Müller, editor.
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical...
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| Online Access: |
Full Text (via Springer) |
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Springer,
©2013.
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| Series: | AAPS advances in the pharmaceutical sciences series ;
v. 4. |
| Subjects: |
| Summary: | In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development. |
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| Physical Description: | 1 online resource : color illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9781461448150 1461448158 146144814X 9781461448143 |
| ISSN: | 2210-7371 ; |