The genome sequence of Geobacter metallireducens [electronic resource] : features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.
Background: The genome sequence of Geobacter metallireducens is the second to be completed from the metal-respiring genus Geobacter, and is compared in this report to that of Geobacter sulfurreducens in order to understand their metabolic, physiological and regulatory similarities and differences. R...
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Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
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Berkeley, Calif. : Oak Ridge, Tenn. :
Lawrence Berkeley National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
2008.
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| Subjects: |
MARC
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| 245 | 0 | 4 | |a The genome sequence of Geobacter metallireducens |h [electronic resource] : |b features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens. |
| 260 | |a Berkeley, Calif. : |b Lawrence Berkeley National Laboratory ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, |c 2008. | ||
| 300 | |a 53 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
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| 500 | |a Published through the Information Bridge: DOE Scientific and Technical Information. | ||
| 500 | |a 12/01/2008. | ||
| 500 | |a "lbnl-2098e" | ||
| 500 | |a BMC Microbiology 1471-2180 FT. | ||
| 500 | |a Land, Miriam L.; DiBartolo, Genevieve; Lapidus, Alla; Lovley, Derek R.; Krushkal, Julia; Aklujkar, Muktak. | ||
| 500 | |a Genomics Division. | ||
| 520 | 3 | |a Background: The genome sequence of Geobacter metallireducens is the second to be completed from the metal-respiring genus Geobacter, and is compared in this report to that of Geobacter sulfurreducens in order to understand their metabolic, physiological and regulatory similarities and differences. Results: The experimentally observed greater metabolic versatility of G. metallireducens versus G. sulfurreducens is borne out by the presence of more numerous genes for metabolism of organic acids including acetate, propionate, and pyruvate. Although G. metallireducens lacks a dicarboxylic acid transporter, it has acquired a second succinate dehydrogenase/fumarate reductase complex, suggesting that respiration of fumarate was important until recently in its evolutionary history. Vestiges of the molybdate (ModE) regulon of G. sulfurreducens can be detected in G. metallireducens, which has lost the global regulatory protein ModE but retained some putative ModE-binding sites and multiplied certain genes of molybdenum cofactor biosynthesis. Several enzymes of amino acid metabolism are of different origin in the two species, but significant patterns of gene organization are conserved. Whereas most Geobacteraceae are predicted to obtain biosynthetic reducing equivalents from electron transfer pathways via a ferredoxin oxidoreductase, G. metallireducens can derive them from the oxidative pentose phosphate pathway. In addition to the evidence of greater metabolic versatility, the G. metallireducens genome is also remarkable for the abundance of multicopy nucleotide sequences found in intergenic regions and even within genes. Conclusion: The genomic evidence suggests that metabolism, physiology and regulation of gene expression in G. metallireducens may be dramatically different from other Geobacteraceae. | |
| 536 | |b DE-AC02-05CH11231. | ||
| 650 | 7 | |a Phosphates. |2 local. | |
| 650 | 7 | |a Electron Transfer. |2 local. | |
| 650 | 7 | |a Genes. |2 local. | |
| 650 | 7 | |a Molybdenum. |2 local. | |
| 650 | 7 | |a Amino Acids. |2 local. | |
| 650 | 7 | |a Ferredoxin. |2 local. | |
| 650 | 7 | |a Dicarboxylic Acids. |2 local. | |
| 650 | 7 | |a Nucleotides. |2 local. | |
| 650 | 7 | |a Organic Acids. |2 local. | |
| 650 | 7 | |a Respiration. |2 local. | |
| 650 | 7 | |a Oxidoreductases. |2 local. | |
| 650 | 7 | |a Physiology. |2 local. | |
| 650 | 7 | |a Origin. |2 local. | |
| 650 | 7 | |a Molybdates. |2 local. | |
| 650 | 7 | |a Enzymes. |2 local. | |
| 650 | 7 | |a Pentoses. |2 local. | |
| 650 | 7 | |a Biosynthesis. |2 local. | |
| 650 | 7 | |a Proteins. |2 local. | |
| 650 | 7 | |a Regulations. |2 local. | |
| 650 | 7 | |a Metabolism. |2 local. | |
| 710 | 2 | |a Lawrence Berkeley National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
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