Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme [electronic resource]
This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM...
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| Online Access: |
Online Access |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
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Washington, D.C. : Oak Ridge, Tenn. :
United States. Dept. of Energy. Office of Biological and Environmental Research ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
2006.
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| Summary: | This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor. Ldl Receptor Microemulsion Synthetic Nano-ldl. |
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| Item Description: | Published through the Information Bridge: DOE Scientific and Technical Information. 06/14/2006. "lbnl--60496" ": KP1102020" International Journal of Pharmaceutics 328 1 ISSN 0378-5173; IJPHDE FT. Journal Publication Date: 07/31/2006. Budinger, Thomas F.; Forte, Trudy M.; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Nikanjam, Mina. |