FDA Approved Registration of Erythromycin for Treatment of Bacterial Kidney Disease (BKD) in Juvenile and Adult Chinook Salmon Annual Report, Reporting Period March 10, 1989 to March 9, 1990.

FDA Approved Registration of Erythromycin for Treatment of Bacterial Kidney Disease (BKD) in Juvenile and Adult Chinook Salmon [electronic resource] : Annual Report, Reporting Period March 10, 1989 to March 9, 1990.

Erythromycin is a therapeutic substance useful against bacterial kidney disease in salmon. In 1989 we began a multi year project to learn more about erythromycin applied to juvenile and adult salmon, with the goal of achieving registration of erythromycin with the US Food and Drug Administration. To...

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Bibliographic Details
Online Access: Online Access (via OSTI)
Corporate Author: University of Idaho (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Portland, Ore. : Oak Ridge, Tenn. : United States. Bonneville Power Administration ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, 1991.
Subjects:
Anadromous Fishes.
Bacterial Diseases.
Erythromycin.
Pharmacology.
Urogenital System Diseases.
Therapy.
Bonneville Power Administration.
Columbia River Basin.
Experiment Planning.
Feasibility Studies.
Fisheries.
Ingestion.
Injection.
Juveniles.
Progress Report.
Salmon.
Tissue Distribution.
Us Fda.
Animals.
Antibiotics.
Aquatic Organisms.
Diseases.
Distribution.
Document Types.
Drugs.
Fishes.
Infectious Diseases.
Intake.
National Organizations.
Planning.
Us Doe.
Anti-Infective Agents.
Us Hew.
Us Organizations.
Vertebrates.
Radiology And Nuclear Medicine.
Basic Biological Sciences.
Hydro Energy.
Description
Summary:Erythromycin is a therapeutic substance useful against bacterial kidney disease in salmon. In 1989 we began a multi year project to learn more about erythromycin applied to juvenile and adult salmon, with the goal of achieving registration of erythromycin with the US Food and Drug Administration. To begin the study, we studied the pharmacokinetics of erythromycin administered to both adult and juvenile chinook salmon. We monitored blood plasmas time curves from individual adult fish injected with two forms of injectable erythromycin using one of three routes of administration. In addition, we began experiments to evaluate hatchery applications of erythromycin to individually marked adult salmon, and we recovered blood tissues from these fish at the time of spawning. To determine how to use erythromycin in juvenile salmon, we evaluated the adsorption and elimination of erythromycin applied arterially and orally to individual juvenile fish. In feeding trials we determined the palatability to juvenile chinook salmon of feed made with one of two different carriers for erythromycin thiocyanate. 35 refs., 4 figs. , 3 tabs.
Bacterial Kidney Disease (Fish Disease) - Treatment.
Item Description:Published through SciTech Connect.
04/01/1991.
"doe/bp-96247-1"
"DE91017166"
Moffitt, Christine A.
Physical Description:46 pages : digital, PDF file.

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