On the cells of origin of radiogenic thyroid cancer [electronic resource] : New studies based on an old idea.
We have presented evidence that the functional thyroid follicles (follicular units, FU) which are formed in grafts of monodispersed rat thyroid cells, and hence the thyroid tumors which later develop in such grafts, are clonal in origin. Recent studies have been designed to investigate: whether cell...
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| Online Access: |
Online Access |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1990.
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| Subjects: |
MARC
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| 086 | 0 | |a E 1.99:conf-901274-2 | |
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| 088 | |a conf-901274-2 | ||
| 245 | 0 | 0 | |a On the cells of origin of radiogenic thyroid cancer |h [electronic resource] : |b New studies based on an old idea. |
| 260 | |a Washington, D.C. : |b United States. Department of Energy ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1990. | ||
| 300 | |a Pages: (27 p) : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 01/01/1990. | ||
| 500 | |a "conf-901274-2" | ||
| 500 | |a "DE92004031" | ||
| 500 | |a International symposium on radiation carcinogenesis in the whole-body system, Tokyo (Japan), 5-6 Dec 1990. | ||
| 500 | |a Domann, F.E.; Clifton, K.H.; Groch, K.M. | ||
| 520 | 3 | |a We have presented evidence that the functional thyroid follicles (follicular units, FU) which are formed in grafts of monodispersed rat thyroid cells, and hence the thyroid tumors which later develop in such grafts, are clonal in origin. Recent studies have been designed to investigate: whether cell number-dependent inhibition of promotion-progression is mediated by remote hormonal feed-back, local cell-cell interactions, or both; the cell population kinetics of the clonogen subpopulation during goitrogenesis and goiter involution; and the effect of prolonged exposure to high levels of TSH (thyrotropin) on the capacity of the clonogens to give rise to functional FU. The results indicate that local cell-cell interactions play an important role in the cell number-dependent suppression of neoplastic promotion-progression. They also show that if sufficient thyroid cells are grafted, the thyroid-pituitary axis can be reestablished in thyroidectomized rats fed normal diets. In such animals given iodine deficient diets, the FU that develop in the thyroid grafts shift their secretory pattern to increase the ratio of T3 (triiodothyronine) to T4 (thyroxine), and thus conserve the available iodine. Finally, the clonogenic subpopulation is conserved during both goitrogenesis and goiter involution. When they are transplanted to thyroidectomized recipients, clonogens from two types of goiters form FU that are morphologically indistinguishable from those that develop in grafts of normal thyroid clonogens. Furthermore, the secretion of T3 and T4 by such grafts is dependent on the grafted clonogen number, and hence FU formation, and not on the total number of thyroid cells transplanted. We conclude that the thyroid clonogens, the presumptive cancer progenitor cells, have many of the characteristics of stem cells. | |
| 536 | |b FG02-87ER60507. | ||
| 650 | 7 | |a Carcinogenesis. |2 local. | |
| 650 | 7 | |a Biological Pathways. |2 local. | |
| 650 | 7 | |a Neoplasms. |2 local. | |
| 650 | 7 | |a Radioinduction. |2 local. | |
| 650 | 7 | |a Thyroid. |2 local. | |
| 650 | 7 | |a Biological Radiation Effects. |2 local. | |
| 650 | 7 | |a Cell Cultures. |2 local. | |
| 650 | 7 | |a Cell Differentiation. |2 local. | |
| 650 | 7 | |a Clone Cells. |2 local. | |
| 650 | 7 | |a Goiter. |2 local. | |
| 650 | 7 | |a Grafts. |2 local. | |
| 650 | 7 | |a Hormones. |2 local. | |
| 650 | 7 | |a Ionizing Radiations. |2 local. | |
| 650 | 7 | |a Rats. |2 local. | |
| 650 | 7 | |a Stem Cells. |2 local. | |
| 650 | 7 | |a Thyroxine. |2 local. | |
| 650 | 7 | |a Triiodothyronine. |2 local. | |
| 650 | 7 | |a Tsh. |2 local. | |
| 650 | 7 | |a Amino Acids. |2 local. | |
| 650 | 7 | |a Animal Cells. |2 local. | |
| 650 | 7 | |a Animals. |2 local. | |
| 650 | 7 | |a Biological Effects. |2 local. | |
| 650 | 7 | |a Body. |2 local. | |
| 650 | 7 | |a Carboxylic Acids. |2 local. | |
| 650 | 7 | |a Diseases. |2 local. | |
| 650 | 7 | |a Endocrine Diseases. |2 local. | |
| 650 | 7 | |a Endocrine Glands. |2 local. | |
| 650 | 7 | |a Glands. |2 local. | |
| 650 | 7 | |a Mammals. |2 local. | |
| 650 | 7 | |a Organic Acids. |2 local. | |
| 650 | 7 | |a Organic Compounds. |2 local. | |
| 650 | 7 | |a Organic Halogen Compounds. |2 local. | |
| 650 | 7 | |a Organic Iodine Compounds. |2 local. | |
| 650 | 7 | |a Organs. |2 local. | |
| 650 | 7 | |a Pathogenesis. |2 local. | |
| 650 | 7 | |a Peptide Hormones. |2 local. | |
| 650 | 7 | |a Pituitary Hormones. |2 local. | |
| 650 | 7 | |a Proteins. |2 local. | |
| 650 | 7 | |a Radiation Effects. |2 local. | |
| 650 | 7 | |a Radiations. |2 local. | |
| 650 | 7 | |a Rodents. |2 local. | |
| 650 | 7 | |a Somatic Cells. |2 local. | |
| 650 | 7 | |a Thyroid Hormones. |2 local. | |
| 650 | 7 | |a Transplants. |2 local. | |
| 650 | 7 | |a Vertebrates. |2 local. | |
| 650 | 7 | |a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.. |2 edbsc. | |
| 650 | 7 | |a Basic Biological Sciences. |2 edbsc. | |
| 710 | 2 | |a University of Wisconsin--Madison. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |4 spn. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
| 856 | 4 | 0 | |u http://www.osti.gov/servlets/purl/5930594/ |z Online Access |
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