|
|
|
|
| LEADER |
00000nam a22000003u 4500 |
| 001 |
b5978414 |
| 003 |
CoU |
| 005 |
20080305000000.0 |
| 006 |
m d f |
| 007 |
cr un |
| 008 |
100524e19901201dcu st f0|||||eng|d |
| 035 |
|
|
|a (TOE)ost7185351
|
| 035 |
|
|
|a (TOE)7185351
|
| 040 |
|
|
|a TOE
|c TOE
|
| 049 |
|
|
|a GDWR
|
| 072 |
|
7 |
|a 62
|2 edbsc
|
| 086 |
0 |
|
|a E 1.99:doe/er/60725-1
|
| 086 |
0 |
|
|a E 1.99:doe/er/60725-1
|
| 245 |
0 |
0 |
|a In vivo metabolism of I-123 labeled semisynthetic low density lipoproteins
|h [electronic resource]
|
| 260 |
|
|
|a Washington, D.C. :
|b United States. Dept. of Defense ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 1990.
|
| 300 |
|
|
|a Pages: (10 p) :
|b digital, PDF file.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent.
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia.
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier.
|
| 500 |
|
|
|a Published through the Information Bridge: DOE Scientific and Technical Information.
|
| 500 |
|
|
|a 12/01/1990.
|
| 500 |
|
|
|a "doe/er/60725-1"
|
| 500 |
|
|
|a "DE92040343"
|
| 500 |
|
|
|a Harper, P.V.
|
| 520 |
3 |
|
|a We previously observed that small model beta-strand peptides (MBPs) selectively bind to human low density lipoprotein (hLDL) in vitro, and that some MBPs can be labeled with I-123-tyramine cellobiose (I-123-TyC). We hypothesized that metabolism of semisynthetic hLDL should mimic that of covalently labeled native hLDL, and planned to evaluate the biodistribution in rabbits of semisynthetic hLDL; to determine effects of prior oxidation and acetylation of the adsorbing hLDL on binding of MBPs and upon biodistribution of semisynthetic particles; and to begin biodistribution studies with semisynthetic hLDL in human subjects, with the eventual goal of application to experimental and clinical nuclear imaging studies. We have synthesized a radioiodotyrosine-containing MBP, designated betay, as a more suitable adsorbant to hLDL thanradioiodine-TyC-MBP, and optimized conditions for preparing radioiodine-betaY:hLDL. In rabbits both betaY and betaY:hLDL complexes were cleared from the bloodstream much more rapidly than radioiodine-TyC-hLDL or In-111-hLDL, and betaY in either form showed a biodistribution pattern different from that of directly radiolabeled hLDL. Even though radioiodine-betaY can be quickly and easily produced, we conclude that neither betaY alone nor semisynthetic betaY:hLDL particles are likely to prove useful as tracers of hLDL metabolism in vivo.
|
| 536 |
|
|
|b FG02-88ER60725.
|
| 650 |
|
7 |
|a Labelled Compounds.
|2 local.
|
| 650 |
|
7 |
|a Beta Decay Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a In Vivo.
|2 local.
|
| 650 |
|
7 |
|a Organic Compounds.
|2 local.
|
| 650 |
|
7 |
|a Biological Half-life.
|2 local.
|
| 650 |
|
7 |
|a Document Types.
|2 local.
|
| 650 |
|
7 |
|a Mammals.
|2 local.
|
| 650 |
|
7 |
|a Drugs.
|2 local.
|
| 650 |
|
7 |
|a Lipids.
|2 local.
|
| 650 |
|
7 |
|a Organic Acids.
|2 local.
|
| 650 |
|
7 |
|a Chemical Preparation.
|2 local.
|
| 650 |
|
7 |
|a Labelling.
|2 local.
|
| 650 |
|
7 |
|a Electron Capture Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Primates.
|2 local.
|
| 650 |
|
7 |
|a Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Tissue Distribution.
|2 local.
|
| 650 |
|
7 |
|a Tyrosine.
|2 local.
|
| 650 |
|
7 |
|a Proteins.
|2 local.
|
| 650 |
|
7 |
|a Animals.
|2 local.
|
| 650 |
|
7 |
|a Radiopharmaceuticals.
|2 local.
|
| 650 |
|
7 |
|a Iodine Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Intermediate Mass Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Amino Acids.
|2 local.
|
| 650 |
|
7 |
|a Progress Report.
|2 local.
|
| 650 |
|
7 |
|a Odd-even Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Iodine 123.
|2 local.
|
| 650 |
|
7 |
|a Tracer Techniques.
|2 local.
|
| 650 |
|
7 |
|a Man.
|2 local.
|
| 650 |
|
7 |
|a Lipoproteins.
|2 local.
|
| 650 |
|
7 |
|a Carboxylic Acids.
|2 local.
|
| 650 |
|
7 |
|a Synthesis.
|2 local.
|
| 650 |
|
7 |
|a Hydroxy Acids.
|2 local.
|
| 650 |
|
7 |
|a Isotope Applications.
|2 local.
|
| 650 |
|
7 |
|a Vertebrates.
|2 local.
|
| 650 |
|
7 |
|a Distribution.
|2 local.
|
| 650 |
|
7 |
|a Rabbits.
|2 local.
|
| 650 |
|
7 |
|a Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Metabolism.
|2 local.
|
| 650 |
|
7 |
|a Catabolism.
|2 local.
|
| 650 |
|
7 |
|a Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Hours Living Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Radiology And Nuclear Medicine.
|2 edbsc.
|
| 710 |
2 |
|
|a University of Chicago.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Defense.
|4 spn.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|4 spn.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Chicago Operations Office.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/7185351-EANlat/
|z Online Access
|
| 907 |
|
|
|a .b59784143
|b 03-06-23
|c 05-26-10
|
| 998 |
|
|
|a web
|b 05-26-10
|c f
|d m
|e p
|f eng
|g dcu
|h 0
|i 1
|
| 956 |
|
|
|a Information bridge
|
| 999 |
f |
f |
|i 602a0252-2bba-5994-a7ed-c1d8806b442c
|s c4a45533-7a33-5a53-8661-a9094b541c38
|
| 952 |
f |
f |
|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:doe/er/60725-1
|h Superintendent of Documents classification
|i web
|n 1
|
