|
|
|
|
| LEADER |
00000nam a22000003u 4500 |
| 001 |
b5976472 |
| 003 |
CoU |
| 005 |
20080207000000.0 |
| 006 |
m d f |
| 007 |
cr un |
| 008 |
100524e19900801dcu st f0|||||eng|d |
| 035 |
|
|
|a (TOE)ost6366396
|
| 035 |
|
|
|a (TOE)6366396
|
| 040 |
|
|
|a TOE
|c TOE
|
| 049 |
|
|
|a GDWR
|
| 072 |
|
7 |
|a 62
|2 edbsc
|
| 086 |
0 |
|
|a E 1.99:doe/er/60728-2
|
| 086 |
0 |
|
|a E 1.99:doe/er/60728-2
|
| 245 |
0 |
0 |
|a Labeling cellular elements of blood with Technetium-99m
|h [electronic resource]
|
| 260 |
|
|
|a Washington, D.C :
|b United States. Dept. of Energy. Office of Energy Research ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 1990.
|
| 300 |
|
|
|a Pages: (9 p) :
|b digital, PDF file.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent.
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia.
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier.
|
| 500 |
|
|
|a Published through the Information Bridge: DOE Scientific and Technical Information.
|
| 500 |
|
|
|a 08/01/1990.
|
| 500 |
|
|
|a "doe/er/60728-2"
|
| 500 |
|
|
|a "DE91002371"
|
| 500 |
|
|
|a Dewanjee, M.K.
|
| 520 |
3 |
|
|a The purpose of this proposal is to develop new technique of labeling platelets and white cells with Tc-99m radionuclide. The conditions of labeling canine platelets and white cells with the lipid-soluble Tc-99m HMPAO have been optimized. The function of labeled platelets were evaluated by the determination of platelet survival time and recovery and these values were compared with that of In-111 tropolone labeled platelets. We developed the bilateral femoral catheterization model for the evaluation of platelet-thrombosis on control and heparin-bonded catheters in dogs. We are evaluating platelet thrombosis in the hollow-fiber hemodialyzer with Tc-99m and In-111 labeled platelets. We have developed the flow-loop for in vitro studies and are using a pig model for quantitation of platelet-consumption during hemodialysis. We are currently evaluating the new technique of platelet and white cell-labeling with Tc-99m and testing them in animal models of thrombosis and infection (osteo-myelitis). We are also using the Tc-99m HMPAO labeled mixed white cells in the early diagnosis (3-hour post-injection) of acute and chronic infection in patients and comparing the results with that of IN-111 oxine labeled white cells.
|
| 536 |
|
|
|b FG05-88ER60728.
|
| 650 |
|
7 |
|a Beta Decay Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Blood Platelets.
|2 local.
|
| 650 |
|
7 |
|a Leukocytes.
|2 local.
|
| 650 |
|
7 |
|a Hematologic Agents.
|2 local.
|
| 650 |
|
7 |
|a Document Types.
|2 local.
|
| 650 |
|
7 |
|a Mammals.
|2 local.
|
| 650 |
|
7 |
|a Drugs.
|2 local.
|
| 650 |
|
7 |
|a Labelling.
|2 local.
|
| 650 |
|
7 |
|a Dogs.
|2 local.
|
| 650 |
|
7 |
|a Dialysis.
|2 local.
|
| 650 |
|
7 |
|a Electron Capture Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Cardiovascular Diseases.
|2 local.
|
| 650 |
|
7 |
|a Diseases.
|2 local.
|
| 650 |
|
7 |
|a Isomeric Transition Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Progress Report.
|2 local.
|
| 650 |
|
7 |
|a Urine.
|2 local.
|
| 650 |
|
7 |
|a Tracer Techniques.
|2 local.
|
| 650 |
|
7 |
|a Vascular Diseases.
|2 local.
|
| 650 |
|
7 |
|a Minutes Living Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Body Fluids.
|2 local.
|
| 650 |
|
7 |
|a Isotope Applications.
|2 local.
|
| 650 |
|
7 |
|a Vertebrates.
|2 local.
|
| 650 |
|
7 |
|a Technetium Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Anticoagulants.
|2 local.
|
| 650 |
|
7 |
|a Organic Sulfur Compounds.
|2 local.
|
| 650 |
|
7 |
|a Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Days Living Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Blood.
|2 local.
|
| 650 |
|
7 |
|a Indium Isotopes.
|2 local.
|
| 650 |
|
7 |
|a Organic Compounds.
|2 local.
|
| 650 |
|
7 |
|a Amines.
|2 local.
|
| 650 |
|
7 |
|a Indium 111.
|2 local.
|
| 650 |
|
7 |
|a Separation Processes.
|2 local.
|
| 650 |
|
7 |
|a Blood Cells.
|2 local.
|
| 650 |
|
7 |
|a Beta-minus Decay Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Wastes.
|2 local.
|
| 650 |
|
7 |
|a Diagnostic Techniques.
|2 local.
|
| 650 |
|
7 |
|a Animals.
|2 local.
|
| 650 |
|
7 |
|a Thrombosis.
|2 local.
|
| 650 |
|
7 |
|a Biological Effects.
|2 local.
|
| 650 |
|
7 |
|a Survival Time.
|2 local.
|
| 650 |
|
7 |
|a Intermediate Mass Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Materials.
|2 local.
|
| 650 |
|
7 |
|a Odd-even Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Biological Materials.
|2 local.
|
| 650 |
|
7 |
|a Carbohydrates.
|2 local.
|
| 650 |
|
7 |
|a Heparin.
|2 local.
|
| 650 |
|
7 |
|a Polysaccharides.
|2 local.
|
| 650 |
|
7 |
|a Mucopolysaccharides.
|2 local.
|
| 650 |
|
7 |
|a Saccharides.
|2 local.
|
| 650 |
|
7 |
|a Biological Wastes.
|2 local.
|
| 650 |
|
7 |
|a Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Technetium 99.
|2 local.
|
| 650 |
|
7 |
|a Years Living Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Hours Living Radioisotopes.
|2 local.
|
| 650 |
|
7 |
|a Radiology And Nuclear Medicine.
|2 edbsc.
|
| 710 |
2 |
|
|a University of Miami.
|b School of Medicine.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Energy Research.
|4 spn.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Oak Ridge Operations.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/6366396-CWIqWG/
|z Online Access
|
| 907 |
|
|
|a .b59764727
|b 03-06-23
|c 05-26-10
|
| 998 |
|
|
|a web
|b 05-26-10
|c f
|d m
|e p
|f eng
|g dcu
|h 0
|i 1
|
| 956 |
|
|
|a Information bridge
|
| 999 |
f |
f |
|i e56cbf2e-ad16-5a7c-9838-386f60a8790f
|s acc8d19a-221e-5ae4-9341-0d882eed6750
|
| 952 |
f |
f |
|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:doe/er/60728-2
|h Superintendent of Documents classification
|i web
|n 1
|
