Wnt signaling in development and disease : molecular mechanisms and biological functions / [edited by] Stefan Hoppler, Randall T. Moon.
"Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signali...
Saved in:
| Online Access: |
Full Text (via Wiley) |
|---|---|
| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Hoboken, New Jersey :
Wiley Blackwell,
[2014]
|
| Subjects: |
Table of Contents:
- Wnt Signaling in Development and Disease; Copyright; Contents; Contributors; Preface; Part 1 Molecular Signaling Mechanisms: From Pathways to Networks; 1 Wnt Signal Production, Secretion, and Diffusion; Introduction; Posttranslational modification of Wnt; The Wnt secretion pathway; Mechanisms that promote and control the diffusion of Wnt; Conclusions and perspectives; References; 2 Wnt Signaling at the Membrane; Introduction; The Frizzled family of Wnt receptors; The LRP family of Wnt coreceptors; References.
- Wnt/rho/ ROCK and Wnt/rac/ JNK signalingWnt/Ror signaling; Wnt/Ryk signaling; Wnt/ cAMP /protein kinase A; Wnt/ TOR signaling; Outlook; References; 7 Molecular Mechanisms of Wnt Pathway Specificity; Early Wnt classifications; Wnt5a exemplifies the ability of Wnts to activate multiple signaling cascades; Multiple signaling routes through single Frizzled family members; Determinants of Wnt pathway specificity; Perspectives; Acknowledgments; References; 8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes; Introduction; Endocytic pathways.