Accounts in drug discovery [electronic resource] : case studies in medicinal chemistry / [edited by] Joel Barrish, Percy Carter, Robert Zahler.
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lea...
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| Online Access: |
Full Text (via RSC) |
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| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cambridge :
Royal Society of Chemistry,
[2010], ©2011.
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| Series: | RSC drug discovery series ;
4. |
| Subjects: |
Table of Contents:
- The discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza : from concept to market / Jeffrey A. Robl and Lawrence G. Hamann
- The discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects / Samuel Chackalamannil
- The discovery of Piragliatin, a glucokinase activator / Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby
- The discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors / Mark J. Mulvihill and Elizabeth Buck
- The genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia / Philip R. Hamann
- Novel androgen receptor antagonists for the treatment of prostate cancer / Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite
- The discovery of UK-390957 : the challenge of targeting a short half-life, rapid Tmax SSRI / Mark D. Andrews and Donald S. Middleton
- The discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension / Andrew S. Bell and Michael J. Palmer
- From HTS to market : the discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV / Chris Barber and David Pryde
- The discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor / Richard Mackman
- 2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus : from discovery to the clinic / Michael J. Sofia, Phillip A. furman and William T. Symonds
- A case history on the challenges of central nervous system and dual pharmacology drug discovery / Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock
- The discovery of TRPV1 antagonists : turning up the heat / Mark H. Norman
- Uncoupling neuroprotection from immunosuppression : the discovery of ILS-920 / Edmund I. Graziani
- Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia / Bruce N. Rogers [and others]