Accounts in drug discovery [electronic resource] : case studies in medicinal chemistry / [edited by] Joel Barrish, Percy Carter, Robert Zahler.
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lea...
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| Online Access: |
Full Text (via RSC) |
|---|---|
| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cambridge :
Royal Society of Chemistry,
[2010], ©2011.
|
| Series: | RSC drug discovery series ;
4. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Accounts in drug discovery |h [electronic resource] : |b case studies in medicinal chemistry / |c [edited by] Joel Barrish, Percy Carter, Robert Zahler. |
| 260 | |a Cambridge : |b Royal Society of Chemistry, |c [2010], ©2011. | ||
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| 490 | 1 | |a RSC Drug Discovery ; |v 4. | |
| 505 | 0 | 0 | |t The discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza : |t from concept to market / |r Jeffrey A. Robl and Lawrence G. Hamann -- |t The discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects / |r Samuel Chackalamannil -- |t The discovery of Piragliatin, a glucokinase activator / |r Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby -- |t The discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors / |r Mark J. Mulvihill and Elizabeth Buck -- |t The genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia / |r Philip R. Hamann -- |t Novel androgen receptor antagonists for the treatment of prostate cancer / |r Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite -- |t The discovery of UK-390957 : |t the challenge of targeting a short half-life, rapid Tmax SSRI / |r Mark D. Andrews and Donald S. Middleton -- |t The discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension / |r Andrew S. Bell and Michael J. Palmer -- |t From HTS to market : |t the discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV / |r Chris Barber and David Pryde -- |t The discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor / |r Richard Mackman -- |t 2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus : |t from discovery to the clinic / |r Michael J. Sofia, Phillip A. furman and William T. Symonds -- |t A case history on the challenges of central nervous system and dual pharmacology drug discovery / |r Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock -- |t The discovery of TRPV1 antagonists : |t turning up the heat / |r Mark H. Norman -- |t Uncoupling neuroprotection from immunosuppression : |t the discovery of ILS-920 / |r Edmund I. Graziani -- |t Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia / |r Bruce N. Rogers [and others] |
| 520 | |a Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening ""hits"" as well as rational, structure-based design. The chapters include ""follow-ons"" and ""next generation"" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal. | ||
| 588 | 0 | |a Online resource; title from title screen (viewed on June 15, 2010) | |
| 650 | 0 | |a Drug development |v Case studies. | |
| 650 | 0 | |a Pharmaceutical chemistry |v Case studies. | |
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| 650 | 7 | |a Pharmaceutical chemistry. |2 fast |0 fst01060115 | |
| 655 | 7 | |a Case studies. |2 fast |0 fst01423765 | |
| 700 | 1 | |a Barrish, Joel Charles, |d 1957- |0 http://id.loc.gov/authorities/names/n85809901 |1 http://isni.org/isni/0000000028720502. | |
| 700 | 1 | |a Carter, Percy. |0 http://id.loc.gov/authorities/names/n91023505 | |
| 700 | 1 | |a Zahler, Robert. | |
| 776 | 0 | 8 | |i Print version: |t Accounts in drug discovery. |d Cambridge : Royal Society of Chemistry, [2010], ©2011 |z 9781849731263 |z 1849731268 |w (OCoLC)671469689. |
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