Flow chemistry in drug discovery /

Flow chemistry in drug discovery / Jesus Alcazar, Antonio de la Hoz, Angel Díaz-Ortiz, editors ; with contributions by I. Abdiaj [and 30 others]

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental met...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Alcazar, Jesus (Editor), Hoz, Antonio de la (Editor), Díaz-Ortiz, Angel (Editor)
Format: eBook
Language:English
Published: Cham : Springer, [2021]
Series:Topics in medicinal chemistry (Springer (Firm)) ; v. 38.
Subjects:
Drug development.
Flow chemistry.
Table of Contents:
  • Intro
  • Preface
  • Contents
  • List of Abbreviations
  • Flow Chemistry in Drug Discovery: Challenges and Opportunities
  • 1 Introduction
  • 1.1 Introduction to Flow Chemistry
  • 1.2 Flow Chemistry Setup
  • 1.3 Types of Transformations
  • 2 The Drug Discovery Process in Pharma
  • 3 Flow Chemistry as a Tool to Improve Drug Discovery
  • 3.1 Green Components of Flow Chemistry
  • 3.2 Diversity Oriented Synthesis (DOS) in Flow
  • 3.3 Catalysis in Flow
  • 3.3.1 Hetero- and Homogeneous Catalysis
  • 3.3.2 Biocatalysis
  • 3.3.3 Photocatalysis
  • 3.4 Electrochemistry in Flow.
  • 3.5 Library Synthesis and Automation Using Flow
  • 3.6 Artificial Intelligence (AI) and Flow Chemistry
  • 4 Conclusions and Outlook
  • References
  • Green Aspects of Flow Chemistry for Drug Discovery
  • 1 Introduction
  • 2 Solvents
  • 2.1 Supercritical Fluids and Ionic Liquids
  • 2.2 Deep Eutectic Solvents
  • 2.3 Biomass-Derived Solvents
  • 2.4 Miscellaneous
  • 3 Enabling Technologies
  • 3.1 Photochemistry
  • 3.2 Electrochemistry
  • 3.3 Biocatalysis
  • 3.4 Microwaves
  • 4 Hazardous Reagents
  • 4.1 Azides
  • 4.2 Diazomethane
  • 4.3 Hydrogenation
  • 4.4 Carbonylation
  • 4.5 Miscellaneous.
  • 5 Monitoring, Optimization, and Scale-Up in the Pharmaceutical Industry
  • 5.1 Monitoring
  • 5.2 Automatization
  • 5.3 3D Printing
  • 5.4 Optimization
  • 5.5 Process Intensification and Scale-Up
  • 6 Quantification of Sustainability (LCA)
  • 7 Conclusions
  • References
  • Photochemistry in Flow for Drug Discovery
  • 1 Introduction
  • 2 Carbon-Carbon and Carbon-Heteroatom Bond Formation
  • 2.1 Diazonium Salts and Diazo Compounds for C-C and C-X Bond Formation
  • 2.2 Photoinduced Metal- and Dye-Catalysed C-C and C-X Bond Formation
  • 2.3 C-C Bond Formation via Photodecarboxylation.
  • 3 Photochemical Cyclization Reactions
  • 4 Photochemical Rearrangement Reactions
  • 5 Incorporation of Fluorine and Fluorine-Containing Groups
  • 6 Trend to Photochemical-Assisted Biocatalysis
  • 7 Summary
  • References
  • Electrochemistry in Flow for Drug Discovery
  • 1 Introduction
  • 1.1 General Introduction
  • 1.2 Introduction to Electrochemistry
  • 1.3 Fundamentals of Organic Electrochemistry
  • 1.4 Methods for Organic Electrosynthesis
  • 1.4.1 Controlled Potential Electrolysis (Potentiostatic)
  • 1.4.2 Constant Current Electrolysis (Galvanostatic)
  • 1.5 Cyclic Voltammetry.
  • 1.6 Direct vs Indirect Electrolysis
  • 1.7 Types of Cells
  • 1.7.1 Batch Cells
  • 1.7.2 Flow Electrochemical Reactors
  • Parallel Plate Flow Cells
  • Thin-Layer Flow Cells
  • Porous Flow Cells
  • Automated Flow Electrolysis Platforms
  • 2 Flow Electrochemistry for Drug Discovery
  • 2.1 Flow Electrosynthesis of Pharmaceutically Relevant Scaffolds/Fragments
  • 2.1.1 Electrochemical Synthesis of Nitrile-Containing Scaffolds
  • 2.1.2 Electrochemical Synthesis of Benzoxazoles and Benzothiazoles
  • 2.1.3 Electrosynthesis of N-Containing Heterocycles by Nitrogen-Centred Radicals.

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