Flow chemistry in drug discovery / Jesus Alcazar, Antonio de la Hoz, Angel Díaz-Ortiz, editors ; with contributions by I. Abdiaj [and 30 others]
This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental met...
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Full Text (via Springer) |
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer,
[2021]
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| Series: | Topics in medicinal chemistry (Springer (Firm)) ;
v. 38. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Flow chemistry in drug discovery / |c Jesus Alcazar, Antonio de la Hoz, Angel Díaz-Ortiz, editors ; with contributions by I. Abdiaj [and 30 others] |
| 264 | 1 | |a Cham : |b Springer, |c [2021] | |
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| 490 | 1 | |a Topics in medicinal chemistry ; |v volume 38. | |
| 505 | 0 | |a Intro -- Preface -- Contents -- List of Abbreviations -- Flow Chemistry in Drug Discovery: Challenges and Opportunities -- 1 Introduction -- 1.1 Introduction to Flow Chemistry -- 1.2 Flow Chemistry Setup -- 1.3 Types of Transformations -- 2 The Drug Discovery Process in Pharma -- 3 Flow Chemistry as a Tool to Improve Drug Discovery -- 3.1 Green Components of Flow Chemistry -- 3.2 Diversity Oriented Synthesis (DOS) in Flow -- 3.3 Catalysis in Flow -- 3.3.1 Hetero- and Homogeneous Catalysis -- 3.3.2 Biocatalysis -- 3.3.3 Photocatalysis -- 3.4 Electrochemistry in Flow. | |
| 505 | 8 | |a 3.5 Library Synthesis and Automation Using Flow -- 3.6 Artificial Intelligence (AI) and Flow Chemistry -- 4 Conclusions and Outlook -- References -- Green Aspects of Flow Chemistry for Drug Discovery -- 1 Introduction -- 2 Solvents -- 2.1 Supercritical Fluids and Ionic Liquids -- 2.2 Deep Eutectic Solvents -- 2.3 Biomass-Derived Solvents -- 2.4 Miscellaneous -- 3 Enabling Technologies -- 3.1 Photochemistry -- 3.2 Electrochemistry -- 3.3 Biocatalysis -- 3.4 Microwaves -- 4 Hazardous Reagents -- 4.1 Azides -- 4.2 Diazomethane -- 4.3 Hydrogenation -- 4.4 Carbonylation -- 4.5 Miscellaneous. | |
| 505 | 8 | |a 5 Monitoring, Optimization, and Scale-Up in the Pharmaceutical Industry -- 5.1 Monitoring -- 5.2 Automatization -- 5.3 3D Printing -- 5.4 Optimization -- 5.5 Process Intensification and Scale-Up -- 6 Quantification of Sustainability (LCA) -- 7 Conclusions -- References -- Photochemistry in Flow for Drug Discovery -- 1 Introduction -- 2 Carbon-Carbon and Carbon-Heteroatom Bond Formation -- 2.1 Diazonium Salts and Diazo Compounds for C-C and C-X Bond Formation -- 2.2 Photoinduced Metal- and Dye-Catalysed C-C and C-X Bond Formation -- 2.3 C-C Bond Formation via Photodecarboxylation. | |
| 505 | 8 | |a 3 Photochemical Cyclization Reactions -- 4 Photochemical Rearrangement Reactions -- 5 Incorporation of Fluorine and Fluorine-Containing Groups -- 6 Trend to Photochemical-Assisted Biocatalysis -- 7 Summary -- References -- Electrochemistry in Flow for Drug Discovery -- 1 Introduction -- 1.1 General Introduction -- 1.2 Introduction to Electrochemistry -- 1.3 Fundamentals of Organic Electrochemistry -- 1.4 Methods for Organic Electrosynthesis -- 1.4.1 Controlled Potential Electrolysis (Potentiostatic) -- 1.4.2 Constant Current Electrolysis (Galvanostatic) -- 1.5 Cyclic Voltammetry. | |
| 505 | 8 | |a 1.6 Direct vs Indirect Electrolysis -- 1.7 Types of Cells -- 1.7.1 Batch Cells -- 1.7.2 Flow Electrochemical Reactors -- Parallel Plate Flow Cells -- Thin-Layer Flow Cells -- Porous Flow Cells -- Automated Flow Electrolysis Platforms -- 2 Flow Electrochemistry for Drug Discovery -- 2.1 Flow Electrosynthesis of Pharmaceutically Relevant Scaffolds/Fragments -- 2.1.1 Electrochemical Synthesis of Nitrile-Containing Scaffolds -- 2.1.2 Electrochemical Synthesis of Benzoxazoles and Benzothiazoles -- 2.1.3 Electrosynthesis of N-Containing Heterocycles by Nitrogen-Centred Radicals. | |
| 520 | |a This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed December 28, 2021) | |
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| 700 | 1 | |a Alcazar, Jesus, |e editor. | |
| 700 | 1 | |a Hoz, Antonio de la, |e editor. |0 http://id.loc.gov/authorities/names/no2013007395 |1 http://isni.org/isni/0000000400101186. | |
| 700 | 1 | |a Díaz-Ortiz, Angel, |e editor. | |
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