HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings

HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings [electronic resource]

We describe a novel interaction between HIV-1 Rev and microtubules (MTs) that results in the formation of bilayered rings that are 44?49 nm in external diameter, 3.4?4.2 MD (megadaltons) in mass, and have 28-, 30-, or 32-fold symmetry. Ring formation is not sensitive to taxol, colchicine, or microtu...

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Online Access: Full Text (via OSTI)
Corporate Authors: National Institutes of Health (U.S.) (Researcher), United States. Department of Energy. Office of Scientific and Technical Information
Format: Government Document Electronic eBook
Language:English
Published: Washington, D.C. : Oak Ridge, Tenn. : United States. Department of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, 2000.
Subjects:
59 basic biological sciences
Cell biology
Acquired immunodeficiency syndrome
Hiv1 rev
Kinesin
Microtubules
Tubulin
Basic biological sciences
Hiv-1 rev

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Call Number: E 1.99:1625119
E 1.99:1625119 Available

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