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Inhibitors of cyclin-dependent kinases as anti-tumor agents [electronic resource] / edited by Paul J. Smith, Eddy W. Yue.

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Bibliographic Details
Online Access: Full Text (via Taylor & Francis)
Other Authors: Smith, Paul J. (Paul James), 1953-, Yue, Eddy W.
Format: Electronic eBook
Language:English
Published: Boca Raton : CRC/Taylor & Francis, ©2007.
Series:CRC enzyme inhibitors series.
Subjects:
Cyclin-dependent kinases > Inhibitors.
Cyclin-dependent kinases > Inhibitors > Therapeutic use > Testing.
Cancer > Chemotherapy.
Table of Contents:
  • Part Section 1: Integration of Cell Cycle Control Pathways and the Oppertunities for Targeting
  • chapter 1 Cell Cycle Dynamics and the Challenges for CDK Targeting
  • chapter 2 Functional Regulation of CIP/KIP CDK Inhibitors
  • chapter 3 Mouse Models to Study the In Vivo Fuction of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor Development
  • chapter 4 Cyclin-Dependent Kinase Inhibitors and Vascular Disease
  • part Section II: CDK Inhibitors: Targets and Their Evaluation
  • chapter 5 Evaluation of CDK Inhibitor Selectivity: From Affinity Chromatography to Yeast Genetics
  • chapter 6 Development of CDK Inhibitors as Anticancer Agents: From Rational Design to CDK4-Specific Inhibition
  • chapter 7 Three-Dimensional Structures of Cyclin- Dependent Kinases and Their Inhibitor Complexes
  • part Section III: CDK Inhibitors: Chemistry Focus
  • chapter 8 Cyclin-Dependent Kinase Small Molecule Modulators for Cancer Therapy
  • chapter 9 (R)-Roscovitine (CYC202, Seliciclib)
  • chapter 10 Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors
  • chapter 11 Discovery of BMS-387032, a Potent Cyclin-Dependent Kinase Inhibitor in Clinical Development
  • chapter 12 Oxindole Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents
  • chapter 13 Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors
  • chapter 14 Development of Indolocarbazoles as Cyclin D1/CDK4 Inhibitors
  • chapter 15 Pyrazoles as Efficient Adenine-Mimetic Heterocycles for the Discovery of CDK Inhibitors
  • chapter 16 Pyrazolo[3,4-d]pyrimidin- 4-ones: Exploring the Structural Determinants of Potency and Selectivity in Cyclin-Dependent Kinase Inhibition
  • part Section IV: Therapeutic Perspective
  • chapter 17 Cyclin-Dependent Kinase Inhibitors and Combination Therapy: Experimental and Clinical Status
  • chapter 18 CDK Inhibitors as Anticancer Agents: Perspectives for the Future.

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