Ion channels and calcium signaling in the microcirculation /

Ion channels and calcium signaling in the microcirculation / edited by William F. Jackson.

"Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance...

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Bibliographic Details
Online Access: Full Text (via ScienceDirect)
Other Authors: Jackson, William F. (William Francis) (Editor)
Format: eBook
Language:English
Published: Amsterdam, The Netherlands : Elsevier Academic Press, 2020.
Edition:First edition.
Series:Current topics in membranes ; v. 85.
Subjects:
Microcirculation.
Ion channels.
Calcium channels.
Table of Contents:
  • Front Cover
  • Ion Channels and Calcium Signaling in the Microcirculation
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Acknowledgments
  • Chapter One: Introduction to ion channels and calcium signaling in the microcirculation
  • 1. What is the microcirculation?
  • 2. What are the components of the microcirculation?
  • 2.1. Feed arteries and arterioles
  • 2.2. Capillaries
  • 2.3. Venules
  • 2.4. Lymphatics
  • 3. Ion channels and Ca signaling in the microcirculation
  • 4. Ion channels and the microcirculation: Future directions
  • References.
  • Chapter Two: Ion channels and the regulation of myogenic tone in peripheral arterioles
  • 1. Introduction
  • 2. Overview of myogenic tone in arterioles and resistance arteries
  • 3. Mechanisms of myogenic tone in peripheral arterioles: Role of mechanosensitive G-protein-coupled receptors and inosito ...
  • 4. VGCCs and myogenic tone in peripheral arterioles
  • 4.1. Non-selective cation channels and myogenic tone in peripheral arterioles
  • 4.2. Ca channels and myogenic tone in peripheral arterioles
  • 4.3. Lack of a role for PKC in arteriolar myogenic tone in peripheral arterioles.
  • 4.4. Rho kinase and myogenic tone in peripheral arterioles
  • 4.5. Ion channels opposing myogenic tone in peripheral arterioles
  • 5. Summary and perspectives
  • Acknowledgment
  • Disclaimers
  • Disclosures
  • References
  • Chapter Three: Endothelial inwardly-rectifying K channels as a key component of shear stress-induced mechanotransduction
  • 1. Introduction
  • 2. Arterial hemodynamic environments and general principles of endothelial flow sensation
  • 2.1. Role of shear stress in conduit arteries
  • 2.2. Role of shear stress in resistance arteries
  • 2.3. Principles of flow sensation.
  • 2.3.1. Adhesion mechanosensitive complex
  • 2.3.2. Apical membrane protruding structures
  • 2.3.3. Membrane tension and cytoskeletal deformation
  • 3. Evidence for flow-sensitivity of endothelial ion channels
  • 3.1. Inwardly-rectifying K channels
  • 3.2. Transient receptor potential channel Vallinoid family type 4 (TRPV4)
  • 3.3. Piezo channels
  • 4. The role of Kir channels in endothelial responses to flow
  • 4.1. Role of endothelial Kir in flow-induced vasodilation and NO release
  • 4.2. Role of endothelial Kir in agonist-induced vasodilation.
  • 4.3. Role of endothelial Kir in developmental angiogenesis
  • 5. Cholesterol suppression of Kir channels in endothelial function
  • 5.1. Mechanisms of cholesterol-induced suppression of Kr2 channels
  • 5.2. Cholesterol-induced suppression of endothelial Kir2 channels plays a major role in the loss of flow-induced vasodila ...
  • 6. Conclusions, open questions and future directions
  • Acknowledgments
  • References
  • Chapter Four: Endothelial TRPV4 channels and vasodilator reactivity
  • 1. Introduction
  • 2. Methodologies for studying endothelial TRPV4 channel activity.

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