Nuclear medicine progress report for quarter ending December 31, 1985 [electronic resource]
The first clinical results with the new iodine-123-labeled methylbranched fatty acid, 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), are described in this report. A series of 19 patients were evaluated with (I-123)BMIPP by planar imaging studies. The groups consisted of patients with norm...
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Oak Ridge, Tenn. : Oak Ridge, Tenn. :
Oak Ridge National Laboratory. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1986.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Nuclear medicine progress report for quarter ending December 31, 1985 |h [electronic resource] |
| 260 | |a Oak Ridge, Tenn. : |b Oak Ridge National Laboratory. ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy, |c 1986. | ||
| 300 | |a Pages: 30 : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 500 | |a Published through SciTech Connect. | ||
| 500 | |a 05/01/1986. | ||
| 500 | |a "ornl/tm-9937" | ||
| 500 | |a "DE86011345" | ||
| 500 | |a Knapp, F.F. Jr.; Ambrose, K.R.; Goodman, M.M.; Srivastava, P.C. | ||
| 520 | 3 | |a The first clinical results with the new iodine-123-labeled methylbranched fatty acid, 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), are described in this report. A series of 19 patients were evaluated with (I-123)BMIPP by planar imaging studies. The groups consisted of patients with normal coronary arteries, and patients with single-, double-, and triple-vessel disease. The goal of these studies was to evaluate (I-123)BMIPP for the first time in patients, to analyze regional uptake and wash-out properties, and to compare the results of BMIPP with the straight-chain analogue, (I-123)IPP. The results of wash-out kinetic measurements are described in this report. An important finding was that, in addition to good myocardial images, abnormal (reduced) elimination was observed in patients with coronary artery disease (CAD) which is not observed with other agents such as IPP. Thus, the additional information obtained with BMIPP may be of useful prognostic value. The results of methyl-branching on the subcellular distribution and incorporation into lipid pools of rat hearts using analogues of 19-iodo-18-nonadecenoic acid are also described in this report. 15 figs., 3 tabs. | |
| 536 | |b AC05-84OR21400. | ||
| 650 | 7 | |a Monocarboxylic Acids. |2 local. | |
| 650 | 7 | |a Diagnostic Uses. |2 local. | |
| 650 | 7 | |a Radiopharmaceuticals. |2 local. | |
| 650 | 7 | |a Subcellular Distribution. |2 local. | |
| 650 | 7 | |a Copper 64. |2 local. | |
| 650 | 7 | |a Heart. |2 local. | |
| 650 | 7 | |a Iodine 123. |2 local. | |
| 650 | 7 | |a Osmium 191. |2 local. | |
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| 650 | 7 | |a Body. |2 local. | |
| 650 | 7 | |a Carboxylic Acids. |2 local. | |
| 650 | 7 | |a Cardiovascular System. |2 local. | |
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| 650 | 7 | |a Nuclei. |2 local. | |
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| 650 | 7 | |a Radiology And Nuclear Medicine. |2 edbsc. | |
| 710 | 2 | |a Oak Ridge National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
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