Management of infections in the immunocompromised host / Brahm H. Segal, editor.
This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research....
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| Format: | eBook |
| Language: | English |
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Springer,
[2018]
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Table of Contents:
- Intro; Dedication; Preface; Contents; Contributors; 1: Phagocytes; Origin and Development of Phagocytes; Mononuclear Phagocytes; Granulocytes; Recruitment, Chemotaxis, and Priming; Rolling; Priming; Adhesion; Transendothelial Cell Migration; Phagocytosis and Microbicidal Activity; Phagocytosis; Maturation of Phagosomes; Production of Reactive Oxygen Species; Production of Reactive Nitrogen Species; Oxygen-Independent Antimicrobial Systems; Extracellular Traps (ETs); Antigen Presentation; Concluding Comments; References; 2: T Cell Immunity; Introduction; Origin and Development of T Cells.
- Immunodeficiency in the Absence of B CellsSummary; References; 4: Complement; The Complement System; Historical Aspects; Evolution of the Complement System; Synthesis, Distribution, and Catabolism of Complement; Activation of Complement; The Classical Pathway; The Lectin Pathway; The Alternative Pathway; C3: The Central Component of Complement; Activation of the Alternative Pathway; The "Tickover" Model; The Properdin-Directed Model; The Terminal Complement Pathway: Assembly of the Membrane Attack Complex; The Intracellular Complement System; Inhibition of Complement Activation.
- Fluid-Phase Complement InhibitorsC1 Inhibitor (C1-INH); Factor I; C4b-Binding Protein (C4BP); Factor H (FH) and the FH Family of Proteins; Vitronectin (Vn); Clusterin (Cn); Membrane-Associated Complement Inhibitors; Complement Receptor 1 (CR1; Also Called CD35 or the Immune Adherence Receptor); CD46 (Membrane Cofactor Protein or MCP); CD55 (Decay-Accelerating Factor [DAF]); CD59 (Homologous Restriction Factor 20 (HRF-20), Membrane Attack Complex Inhibitory Factor (MACIF), or Protectin); Complement Receptor of the Immunoglobulin Superfamily (CRIg); Complement Receptors.
- α-Helical AMPs.
- Receptors for C5a and C3aReceptors for C1q; CR2 (CD21); CR3 (Mac-1, CD11b/CD18, or αMβ2-Integrin); CR4 (CD11c/CD18); Functions of Complement; Innate Immunity and the Elimination of Pathogens; Modulation of the Adaptive Immune Response; B Cells and Humoral Immunity; Regulation of T Cells; Autoimmunity: The Disposal of Immune Complexes and Apoptotic Cells; Metabolism; Complement and Cancer; Tissue Regeneration, Organogenesis, and Synaptic Remodeling; Concluding Remarks; References; 5: Antimicrobial Peptides; Introduction; Synthesis of Human AMPs; Functions of AMPs; Classification of AMPs.
- Antigen Presentation of Specific T Cell AntigensT Cell Antigen Receptors; CD4 and CD8 Co-receptors; Costimulatory and Co-inhibitory Receptors; Functional Specialization of T Cell Subsets; Helper T Cells; Cytotoxic T Cells; Regulatory T Cells; Nonconventional T Cells; CD1-Restricted T Cells; γδ T Cells; MAIT Cells; Summary; References; 3: B Cell Immunity; General Information on B Cells; Types of Mature B Cells; Mouse; Human; B Cell Participation in Immune Responses; Germinal Centers; B Cell Memory; Antibody-Secreting Cells; Transcriptional Programs Regulating B Cell Differentiation.